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Updated: Jun 3, 2026

Blastomere Explants to Test for Cell Fate Commitment During Embryonic Development

Blastomere Explants to Test for Cell Fate Commitment During Embryonic Development

Published on: January 26, 2013

Expression pattern of the FoxO1 gene during mouse embryonic development.

Barbara Villarejo-Balcells¹, Sabrina Guichard, Peter W J Rigby

¹Section of Gene Function and Regulation, The Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, United Kingdom.

Gene Expression Patterns : GEP

|March 15, 2011

Summary

This summary is machine-generated.

This study details the dynamic expression of the transcription factor FoxO1 during mouse embryonic development. FoxO1 is crucial in neuroepithelium, vasculature, heart, and skeletal muscle formation, with expression patterns changing significantly over time.

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Radioactive in situ Hybridization for Detecting Diverse Gene Expression Patterns in Tissue

Radioactive in situ Hybridization for Detecting Diverse Gene Expression Patterns in Tissue

Published on: April 27, 2012

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Last Updated: Jun 3, 2026

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Radioactive in situ Hybridization for Detecting Diverse Gene Expression Patterns in Tissue

Radioactive in situ Hybridization for Detecting Diverse Gene Expression Patterns in Tissue

Published on: April 27, 2012

Area of Science:

Developmental Biology
Genetics
Molecular Biology

Background:

The transcription factor FoxO1 plays a critical role in various cellular processes.
Understanding its spatiotemporal expression pattern is essential for elucidating its developmental functions.

Purpose of the Study:

To comprehensively map the expression pattern of FoxO1 throughout mouse embryonic development.
To generate a novel mouse model for studying FoxO1 expression dynamics.

Main Methods:

Screening of the ES cell genetrap repository for FoxO1 expression.
Generation of a novel mouse strain (B6;129P2-Foxo1(Gt(AD0086)Wtsi/JJC)) using a ß-geo reporter.
Collection and analysis of embryo stages from 7.0 to 18.5 days post-coitum (dpc).

Main Results:

FoxO1 expression is dynamic, initially observed in the neuroepithelium and developing vasculature, including early heart formation.
A significant expression switch occurs at 11.5 dpc, with vascular expression decreasing and skeletal muscle expression emerging.
FoxO1 is also expressed in epithelial structures like the olfactory and otic systems, cornea, and gut, with stage-dependent variations. Expression is upregulated in skeletal muscle, vasculature, and neuroepithelium in later fetal stages.

Conclusions:

FoxO1 exhibits a complex and dynamic expression profile during mouse embryogenesis.
Its expression is tightly regulated and associated with the development of key tissues including the nervous system, cardiovascular system, and skeletal muscle.
The generated mouse model provides a valuable tool for future studies on FoxO1 function in development.