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Published on: September 26, 2018
[Risk factors in hypertensive patients without previous cardiovascular events]
Alejandro de la Sierra1, Diego González-Segura,
1Servicio de Medicina Interna, Hospital Mutua Terrassa, Universidad de Barcelona, Terrassa, Barcelona, España. adelasierra@mutuaterrassa.es
Insights
Most hypertensive patients have high cardiovascular risk, largely due to lipid abnormalities. Addressing these lipid issues significantly lowers overall cardiovascular risk categorization in many individuals.
Area of Science:
- Cardiology
- Hypertension Management
- Cardiovascular Risk Stratification
Context:
- Current guidelines emphasize total cardiovascular risk over blood pressure alone.
- Hypertensive patients without prior events require comprehensive risk assessment.
- Understanding risk factor distribution is crucial for effective management.
Purpose:
- To assess cardiovascular risk category distribution in treated hypertensive patients.
- To identify the prevalence of individual risk factors and target organ damage.
- To quantify the impact of specific risk factors on overall risk categorization.
Summary:
- A multicentre study of 6,762 hypertensive patients revealed most are high or very-high risk.
- Lipid alterations were the most prevalent factor (73.6%), followed by advanced age and abdominal obesity.
- Target organ damage included renal dysfunction (24.1%) and left ventricular hypertrophy (16.4%).
Impact:
- Lipid abnormalities significantly impact risk categorization, with 29% of patients reclassified if absent.
- Addressing lipid abnormalities is key for accurate cardiovascular risk assessment in hypertension.
- This highlights the critical role of lipid management in reducing cardiovascular risk.
Background And Objective:
Guidelines recommend management of patients based not only on the degree of blood pressure elevation, but in total cardiovascular risk. The aim of the present study was to evaluate the distribution of cardiovascular risk categories in hypertensive patients without evidence of previous cardiovascular events, as well as the relative contribution of each factor responsible for this distribution.
Patients And Methods:
Cross-sectional, observational, and multicentre study in a cohort of 6,762 treated hypertensive patients, without evidence of previous cardiovascular events. Data responsible for cardiovascular risk stratification (additional cardiovascular risk factors and target organ damage) were collected. The presence of such factors, as well as changes in risk stratification due to individual removal were evaluated.
Results:
Most patients fulfilled criteria of high or very-high cardiovascular risk. Most frequently present factors were lipid alterations (73.6%) followed by advanced age (sex-adjusted) in 50.8% and abdominal obesity (31.7%). Regarding target organ damage, abnormalities in renal function (24.1%), left ventricular hypertrophy (16.4%) and microalbuminuria (10.7%) were the most frequently observed. A 29% of patients would reduce their cardiovascular risk categorization if lipid abnormalities were absent. In comparison, when other risk factors were removed from risk categorization, it affected less than 10% of patients.
Conclusion:
Most of the hypertensive subjects fall in high or very-high cardiovascular risk categories. Lipid abnormalities are the most frequent risk modificator and has the most important quantitative impact in risk categorization.
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