Low-grade serous primary peritoneal carcinoma.
Kathleen M Schmeler1, Charlotte C Sun, Anais Malpica
1Department of Gynecologic Oncology, The University of Texas M.D. Anderson Cancer Center, 1155 Herman Pressler Drive, Houston, TX 77230, USA. kschmele@mdanderson.org
Gynecologic Oncology
|March 15, 2011
Summary
Low-grade serous primary peritoneal cancer (PPC) patients often have persistent disease after initial treatment but experience long overall survival. Further research is needed to optimize treatment for this rare condition.
Area of Science:
- Gynecologic Oncology
- Pathology
- Clinical Research
Background:
- Low-grade serous ovarian carcinoma (LSOC) presents unique clinical features compared to high-grade serous ovarian carcinoma.
- LSOC patients are diagnosed younger, have longer survival, and lower response to platinum chemotherapy.
- Clinical characteristics of low-grade serous primary peritoneal cancer (PPC) are not well-defined.
Purpose of the Study:
- To analyze the clinical and pathological characteristics of women diagnosed with low-grade serous PPC.
- To compare the features of low-grade serous PPC with those of low-grade serous ovarian carcinoma.
Main Methods:
- Retrospective analysis of 53 patients with confirmed low-grade serous PPC.
- Data collected from 1986 to 2009 at a single institution.
- Cases reviewed by a gynecologic pathologist for accurate diagnosis.
Main Results:
- Median age at diagnosis was 51.7 years.
- High rates of persistent or progressive disease (66.7%) post-treatment.
- 5-year progression-free survival (PFS) was 16%, while 5-year overall survival (OS) was 69%.
Conclusions:
- This is the first report on low-grade serous PPC, suggesting similarities to LSOC.
- Patients exhibit high rates of persistent disease but prolonged overall survival.
- Further studies are required to establish optimal treatment strategies for low-grade serous PPC and LSOC.
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