Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

T Cell Types and Functions

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

Regulation of Hematopoietic Stem Cells

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Comparison of Three Different Balanced Sedative-Anaesthetic Protocols in Captive Baboons <i>(Papio hamadryas)</i>.

Veterinary sciences·2025

Same author

Multimodal Management of a Descending Aorta Injury with Penetrating Chest Trauma: A Case Report.

Reports (MDPI)·2025

Same author

Post-transplant pediatric autoimmune hemolytic anemia: donor vs donor or recipient vs self?

Blood transfusion = Trasfusione del sangue·2024

Same author

AI Approach for Enhanced Thalassemia Diagnosis Using Blood Smear Images.

Studies in health technology and informatics·2024

Same author

Enhancing Thrombophilia Risk Prediction Through AI-Based Methodologies.

Studies in health technology and informatics·2024

Same author

miRNAs in the Box: Potential Diagnostic Role for Extracellular Vesicle-Packaged miRNA-27a and miRNA-128 in Breast Cancer.

International journal of molecular sciences·2023

Search research articles

Related Experiment Video

Updated: Jun 3, 2026

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Published on: April 16, 2012

T(reg) cells: collection, processing, storage and clinical use.

Nicola Daniele¹, Maria Cristina Scerpa, Fabiola Landi

¹Immunohematology Section, Tor Vergata University and SIMT, IRCCS Bambino Gesù Pediatric Hospital, Rome, Italy.

Pathology, Research and Practice

|March 15, 2011

Summary

Regulatory T cells (Treg) are crucial for immune balance and preventing self-attack. Understanding their biology and developing clinical applications may lead to new treatments for autoimmune diseases and transplant tolerance.

More Related Videos

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

Related Experiment Videos

Last Updated: Jun 3, 2026

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Published on: April 16, 2012

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

Area of Science:

Immunology
Cell Biology

Background:

T regulatory cells (Treg) are vital for maintaining immune homeostasis and self-tolerance.
Two functional types, naturally occurring and induced Treg cells, are suggested by experimental models.
The immunosuppressive potential of Treg cells offers therapeutic possibilities for various pathological conditions.

Purpose of the Study:

To explore the fundamental biology of T regulatory cells.
To investigate the potential of Treg cells in treating autoimmune disorders and promoting transplant tolerance.
To identify prerequisites for the clinical application of human Treg cells.

Main Methods:

Review of experimental mouse and human models.
Analysis of Treg cell interactions in limiting immune activation.
Evaluation of strategies for Treg cell isolation, expansion, and cryopreservation.

Main Results:

Treg cells limit immune activation through diverse, yet incompletely understood, mechanisms.
The clinical application of Treg cells is contingent upon GMP-compliant manufacturing strategies.
Understanding Treg cell biology is key to developing novel therapeutic strategies.

Conclusions:

Harnessing Treg cell capacity can lead to strategies for preventing autoimmune disorders.
Treg cells play a critical role in establishing tolerance to transplantation.
Efficient GMP-compliant manufacturing is essential for the clinical use of human CD4+ CD25+ CD127(low) FOXP3+ regulatory T cells.