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Protein Import into the Peroxisomes

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Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...

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Peroxisome Staining in Mammalian Cells Using Peroxisome-Specific Probes

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Published on: December 19, 2025

Peroxisomal disorders with infantile seizures.

Jao-Shwann Liang¹, Jyh-Feng Lu

¹Department of Pediatrics and Medical Research, Far Eastern Memorial Hospital, Taipei, Taiwan.

Brain & Development

|March 15, 2011

Summary

This summary is machine-generated.

Peroxisomal disorders (PDs) affect multiple organs and share common symptoms like developmental delay. This review emphasizes the characteristics of infant seizures in various PDs.

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Area of Science:

Biochemistry
Genetics
Pediatrics

Background:

Peroxisomes are vital organelles involved in lipid metabolism, including plasmalogen synthesis and fatty acid oxidation.
Peroxisomal disorders (PDs) are a diverse group of genetic diseases impacting multiple organ systems with variable severity.
Common symptoms across distinct PDs include developmental delay, visual and hearing impairments, and hypotonia in severe cases.

Purpose of the Study:

To provide a comprehensive overview of peroxisomal disorders (PDs).
To specifically highlight and detail the characteristics of epileptic seizures in infants diagnosed with PDs.
To review the current literature on the classification and evolution of epilepsy within the context of PDs.

Main Methods:

Literature review of scientific articles and clinical case studies.
Analysis of clinical presentations and diagnostic criteria for various PDs.
Synthesis of information regarding seizure phenotypes and their progression in affected infants.

Main Results:

PDs exhibit heterogeneous clinical manifestations and variable survival rates.
Infantile presentations frequently include developmental delay, sensory impairments, and hypotonia.
Epileptic seizures are a significant feature in certain PDs, though their classification and evolution require further elucidation.

Conclusions:

PDs represent a complex group of metabolic disorders with significant neurological impact.
Understanding seizure characteristics in infants with PDs is crucial for diagnosis and management.
Further research is needed to fully characterize epilepsy in PDs and guide therapeutic strategies.