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Related Concept Videos

In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

Updated: Jun 3, 2026

Strategies for Assessing Autistic-Like Behaviors in Mice
07:38

Strategies for Assessing Autistic-Like Behaviors in Mice

Published on: September 20, 2024

Autism candidate genes via mouse phenomics.

Terrence F Meehan1, Christopher J Carr1, Jeremy J Jay1

  • 1The Jackson Laboratory, 600 Main St., Bar Harbor, ME 04609, USA.

Journal of Biomedical Informatics
|March 15, 2011
PubMed
Summary
This summary is machine-generated.

Researchers identified new mouse models with autism-like phenotypes using bioinformatics tools. This study enhances understanding of autism spectrum disorder (ASD) genetics and aids in prioritizing candidate genes for future research.

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Published on: July 14, 2016

Area of Science:

  • Genetics and Bioinformatics
  • Neurodevelopmental Disorders
  • Animal Models

Background:

  • Autism spectrum disorders (ASD) are complex developmental disabilities with a significant genetic component.
  • The laboratory mouse serves as a crucial model organism for studying human diseases, including ASD.
  • The Mouse Genome Informatics (MGI) database utilizes the Mammalian Phenotype (MP) ontology to classify mouse models.

Purpose of the Study:

  • To identify novel gene-phenotype associations related to ASD using bioinformatics approaches.
  • To characterize previously unannotated autistic-like phenotypes in mouse models.
  • To leverage mouse models for a better understanding of ASD genetics.

Main Methods:

  • Utilized bioinformatics tools such as Phenologs, MouseNET, and the Ontological Discovery Environment.
  • Analyzed data associated with Mammalian Phenotype (MP) terms to discover gene-phenotype links.
  • Integrated analysis to identify mouse genotypes with potential autistic-like phenotypes.

Main Results:

  • Identified numerous mouse genotypes exhibiting potential autistic-like phenotypes.
  • Found significant overlap between implicated genes in mouse models and genes previously associated with ASD.
  • Highlighted the utility of bioinformatics for predicting and characterizing autism-related phenotypes in mice.

Conclusions:

  • The study successfully identified novel mouse models relevant to autism spectrum disorder research.
  • Bioinformatics tools provide a powerful and generalizable method for candidate gene prioritization in ASD.
  • These findings contribute to a deeper understanding of the genetic underpinnings of ASD.