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Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

SAMe and sexual functioning.

C M Dording1, D Mischoulon, I Shyu

  • 1Depression Clinical and Research Program, Massachusetts General Hospital, Department of Psychiatry, Massachusetts General Hospital, 1 Bowdoin Square, 6th floor, Boston, MA 02114, USA. cdording@partners.org

European Psychiatry : the Journal of the Association of European Psychiatrists
|March 15, 2011
PubMed
Summary
This summary is machine-generated.

Adjunctive S-adenosyl-l-methionine (SAMe) improved sexual functioning in men experiencing antidepressant-induced sexual dysfunction. This treatment showed benefits for arousal and erectile dysfunction, independent of depression symptom improvement.

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Assessment of Sexual Behavior of Male Mice
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04:38

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Published on: March 5, 2020

Area of Science:

  • Psychiatry
  • Pharmacology
  • Sexual Medicine

Background:

  • Sexual dysfunction is a common side effect of antidepressant treatment (ADT), impacting adherence in 58-73% of patients.
  • Developing novel treatments for antidepressant-induced sexual dysfunction (AISD) is crucial.

Purpose of the Study:

  • To investigate if adjunctive S-adenosyl-l-methionine (SAMe) improves sexual functioning compared to placebo in patients with SSRI/SNRI non-response.
  • To assess the efficacy of SAMe in treating sexual dysfunction secondary to antidepressant use.

Main Methods:

  • A 6-week, single-center, randomized, double-blind trial was conducted.
  • Participants received adjunctive SAMe or placebo for SSRI/SNRI non-responders.
  • Sexual functioning was measured using the Massachusetts General Hospital-Sexual Functioning Questionnaire (MGH-SFQ).

Main Results:

  • Adjunctive SAMe significantly reduced arousal dysfunction in men compared to placebo.
  • Adjunctive SAMe significantly reduced erectile dysfunction in men compared to placebo.
  • These improvements were observed independently of changes in depressive symptoms (HDRS-17 scores).

Conclusions:

  • Adjunctive SAMe demonstrates a positive effect on male arousal and erectile dysfunction.
  • The benefits of SAMe on sexual function appear independent of antidepressant efficacy.
  • Further replication studies are warranted to confirm these preliminary findings.