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Related Experiment Video

Updated: Jun 3, 2026

Optic Nerve Sheath Point of Care Ultrasound: Image Acquisition

Optic Nerve Sheath Point of Care Ultrasound: Image Acquisition

Published on: August 18, 2023

Optic nerve sheath diameter in normal-tension glaucoma patients.

Gregor Peter Jaggi¹, Neil Richard Miller, Josef Flammer

¹Department of Ophthalmology, Kantonsspital Aarau, Switzerland.

The British Journal of Ophthalmology

|March 15, 2011

Summary

Patients with normal-tension glaucoma (NTG) show a significantly increased optic nerve sheath diameter (ONSD) compared to healthy individuals. This finding may be linked to optic nerve sheath changes in NTG.

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Area of Science:

Ophthalmology
Neuroscience
Medical Imaging

Background:

Normal-tension glaucoma (NTG) is a form of glaucoma where optic nerve damage occurs despite normal intraocular pressure.
The optic nerve sheath diameter (ONSD) is a potential indicator of intracranial pressure and optic nerve health.

Purpose of the Study:

To compare the ONSD in patients with NTG against a control group without optic nerve or intracranial disease.
To investigate potential ONSD alterations in NTG.

Main Methods:

Computed tomography (CT) of the orbit was performed in 18 NTG patients and 17 age- and gender-matched controls.
The widest intraorbital ONSD was measured using a standardized technique in axial CT sections.
Statistical analysis included independent two-tailed t-tests and Spearman correlation tests.

Main Results:

ONSD was significantly increased in NTG patients (mean ONSD: 7.9-8.0 mm) compared to controls (mean ONSD: 6.1-6.3 mm) (p<0.001).
No significant differences in ONSD were found between genders or between the right and left optic nerves within either group.

Conclusions:

The ONSD is significantly increased in patients with NTG compared to controls.
Possible explanations for increased ONSD in NTG include optic nerve sheath compartmentation or thinning.