Context-dependent function of "GATA switch" sites in vivo

Jonathan W Snow1, Jennifer J Trowbridge, Kirby D Johnson

  • 1Division of Hematology-Oncology, Children's Hospital Boston, Boston, MA, USA.

Blood
|March 15, 2011
PubMed
Summary

Investigating cis-regulatory elements in vivo, this study found that a specific GATA motif region upstream of the Gata2 gene is crucial for maximal expression in hematopoietic stem cells and progenitors.

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