Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anthelminthic Agents01:15

Anthelminthic Agents

Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...
Antiprotozoal Agents01:21

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Pharmacokinetic–Pharmacodynamic Relationship: Influence of Elimination Half-Life on Effect Duration01:23

Pharmacokinetic–Pharmacodynamic Relationship: Influence of Elimination Half-Life on Effect Duration

Drug elimination from the body primarily occurs through metabolic and excretion pathways. Hepatic metabolism transforms lipophilic drugs into hydrophilic forms for excretion, typically via enzymatic processes classified as phase I (modification) and phase II (conjugation). Renal excretion eliminates drugs and metabolites through filtration and secretion in the kidneys. Impairment in liver or kidney function can hinder these processes, delaying drug clearance and extending the drug’s half-life.
Anticholinesterase Agents: Poisoning and Treatment01:26

Anticholinesterase Agents: Poisoning and Treatment

Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Digital Health Center App for Community and National Malaria Surveillance in Cambodia: Implementation Case Study.

JMIR public health and surveillance·2026
Same author

The effects of bioisostere substitution on the antimicrobial and physicochemical properties of supramolecular self-associating amphiphiles.

RSC medicinal chemistry·2026
Same author

Comparison of Crosslinking Reagents and Their Impacts on Bone Derived ECM Hydrogels.

Advanced healthcare materials·2026
Same author

Fmoc-Phe : Fmoc-Leu supramolecular hydrogels with adaptive antibacterial activity.

RSC advances·2026
Same author

Amino acid appended supramolecular self-associating amphiphiles demonstrate dual activity against both MRSA and ovarian cancer.

Chemical science·2026
Same author

An increased throughput workflow to identify ion transport and membrane lysis agents for antimicrobial discovery.

Chemical science·2026

Related Experiment Video

Updated: Jun 3, 2026

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds
07:14

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

Published on: July 11, 2025

Artemisinin Antimalarials: Preserving the "Magic Bullet"

Richard J Maude1, Charles J Woodrow, Lisa J White

  • 1Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University Bangkok 10400, Thailand.

Drug Development Research
|March 15, 2011
PubMed
Summary

Artemisinins are highly effective antimalarial drugs, crucial for combating malaria. However, emerging resistance threatens their efficacy, necessitating urgent global strategies to preserve this vital treatment.

More Related Videos

Lethality Bioassay Using Artemia salina L.
09:09

Lethality Bioassay Using Artemia salina L.

Published on: October 11, 2022

Protocols for Testing the Toxicity of Novel Insecticidal Chemistries to Mosquitoes
09:32

Protocols for Testing the Toxicity of Novel Insecticidal Chemistries to Mosquitoes

Published on: February 13, 2019

Related Experiment Videos

Last Updated: Jun 3, 2026

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds
07:14

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

Published on: July 11, 2025

Lethality Bioassay Using Artemia salina L.
09:09

Lethality Bioassay Using Artemia salina L.

Published on: October 11, 2022

Protocols for Testing the Toxicity of Novel Insecticidal Chemistries to Mosquitoes
09:32

Protocols for Testing the Toxicity of Novel Insecticidal Chemistries to Mosquitoes

Published on: February 13, 2019

Area of Science:

  • Pharmacology
  • Tropical Medicine
  • Drug Development

Background:

  • Artemisinins, derived from traditional Chinese medicine, are potent antimalarials with a wide therapeutic index.
  • Scientific investigation and global dissemination of artemisinin efficacy occurred from the 1970s onwards.
  • Their rapid parasite-killing ability and short half-life were initially thought to confer a low risk of resistance.

Purpose of the Study:

  • To review the historical development and efficacy of artemisinins as antimalarial drugs.
  • To highlight the critical role of artemisinins in current malaria treatment guidelines.
  • To address the emerging threat of artemisinin resistance and its global implications.

Main Methods:

  • Review of historical data and clinical trial evidence on artemisinins.
  • Analysis of artemisinin combination therapy (ACT) impact on malaria prevalence.
  • Assessment of the current threat posed by artemisinin resistance.

Main Results:

  • Artemisinins demonstrate superior efficacy over alternative antimalarials, rapidly clearing parasite stages.
  • Artemisinin combination therapies (ACTs) are recommended globally to minimize resistance risk and have reduced malaria prevalence.
  • Early signs of artemisinin resistance in western Cambodia pose a significant threat to global malaria control.

Conclusions:

  • Artemisinins remain a cornerstone of malaria treatment, but resistance emergence is a critical concern.
  • Preserving the effectiveness of artemisinins requires global collaboration and strategic interventions.
  • Averting the spread of artemisinin resistance is essential to prevent a resurgence of malaria globally.