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Related Concept Videos

Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)01:16

Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)

Ring-opening metathesis polymerization or ROMP involves strained cycloalkenes as starting materials. The mechanism of ROMP proceeds by reacting cycloalkene with Grubbs catalyst to give metallacyclobutane intermediate which undergoes a ring-opening reaction to form new carbene. The new carbene reacts with another molecule of cycloalkene. Repetition of these steps leads to the formation of an unsaturated open-chain polymer product. All these steps are reversible, however, relieving the ring...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Olefin Metathesis Polymerization: Overview01:13

Olefin Metathesis Polymerization: Overview

Recently, the development of olefin metathesis polymerization advanced the field of polymer synthesis. Simply put, the reorganization of substituents on their double bonds between two olefins in the presence of a catalyst is known as the olefin metathesis reaction. The use of metathesis reaction for polymer synthesis is called olefin metathesis polymerization.
Ruthenium-based Grubbs catalyst is the most commonly used catalyst for olefin metathesis polymerization. Grubbs catalyst consists of a...
Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)00:53

Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)

Acyclic diene metathesis polymerization or ADMET polymerization involves cross-metathesis of terminal dienes, such as 1,8-nonadiene, to give linear unsaturated polymer and ethylene. As ADMET is a reversible process, the formed ethylene gas must be removed from the reaction mixture to complete the polymerization process.
Similar to cross-metathesis, ADMET also involves the formation of metallacyclobutane intermediate by [2+2] cycloaddition of one of the double bonds of a terminal diene with...
Cationic Chain-Growth Polymerization: Mechanism00:57

Cationic Chain-Growth Polymerization: Mechanism

The cationic polymerization mechanism consists of three steps: initiation, propagation, and termination. In the initiation step of the polymerization process, the π bond of a monomer gets protonated by the Lewis acid catalyst, which is formed from boron trifluoride and water. The protonation of the π bond generates a carbocation stabilized by the electron‐donating group. In the propagation step, the π bond of the second monomer acts as a nucleophile and attacks the generated carbocation,...

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Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by &#960;-&#960; Stacking Interactions
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pH-Sensitive brush polymer-drug conjugates by ring-opening metathesis copolymerization.

Jiong Zou1, Goran Jafr, Efrosyni Themistou

  • 1Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, New York 14260, USA.

Chemical Communications (Cambridge, England)
|March 15, 2011
PubMed
Summary

New brush polymer-drug conjugates were synthesized using ring-opening metathesis copolymerization. These advanced materials show shielded drugs, good solubility, and controlled release triggered by acidity.

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Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Drug Delivery Systems

Background:

  • Polymer-drug conjugates are crucial in advanced drug delivery.
  • Developing novel polymer architectures with controlled drug release is an ongoing challenge.
  • Brush polymers offer unique structural possibilities for conjugate design.

Purpose of the Study:

  • To introduce a new class of polymer-drug conjugates: brush polymer-drug conjugates.
  • To investigate the preparation and properties of these novel conjugates.
  • To demonstrate acid-triggered drug release from the designed polymer system.

Main Methods:

  • Synthesis of brush polymer-drug conjugates via ring-opening metathesis copolymerization.
  • Structural characterization of the polymer conjugates.
  • Evaluation of drug shielding, water solubility, and nanostructure formation.
  • Assessment of drug release kinetics under acidic conditions.

Main Results:

  • Successfully prepared brush polymer-drug conjugates with well-defined structures.
  • Achieved significant water solubility and well-defined nanostructures.
  • Demonstrated effective shielding of drug moieties within the polymer architecture.
  • Confirmed acid-triggered drug release, indicating responsiveness to pH changes.

Conclusions:

  • Brush polymer-drug conjugates represent a novel and promising platform for drug delivery.
  • The judicious structural design enables controlled drug release and favorable physicochemical properties.
  • This approach holds potential for developing next-generation targeted and responsive therapeutics.