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Updated: Jun 3, 2026

Production of Cardiac Extracellular Matrix from Adult Human Fibroblasts for Culture Dish Coating
Published on: March 22, 2024
Dynamic interactions between the cellular components of the heart and the extracellular matrix
Thomas K Borg1, Troy A Baudino
1Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, USA. BorgT@musc.edu
Abstract:
The heart is composed of both cellular and acellular components that act in a dynamic fashion from birth to death. The cellular components consist of myocytes, fibroblasts, and vascular cells, including endothelium and smooth muscle. Changes in these components are intimately associated with function by altering the mechanical, chemical, and electrical properties of the heart. In future investigations, it will be important to examine these interactions as dynamic changes in response to physiological signals.
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