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Related Concept Videos

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration01:25

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis01:30

Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis

Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...

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Related Experiment Video

Updated: Jun 3, 2026

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes
10:56

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes

Published on: September 15, 2018

Extracorporeal therapies for refractory hypercholesterolemia.

B R Gordon1, S D Saal

  • 1Associate Professor of Clinical Medicine, The Rogosin Institute, New York, New York.

Surgical Technology International
|March 15, 2011
PubMed
Summary

Lowering low-density lipoprotein cholesterol (LDL-C) is crucial for managing coronary artery disease (CAD). Achieving target LDL-C levels significantly reduces cardiac events and mortality, making cholesterol management a key therapeutic strategy.

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Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
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Published on: January 25, 2015

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Last Updated: Jun 3, 2026

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes
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A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes

Published on: September 15, 2018

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
09:52

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma

Published on: January 25, 2015

Area of Science:

  • Cardiology
  • Metabolic Disorders
  • Public Health

Background:

  • Established link between elevated low-density lipoprotein cholesterol (LDL-C) and coronary artery disease (CAD) development.
  • Proven benefits of LDL-C reduction on cardiac and overall mortality.
  • National guidelines recommend specific LDL-C goals for CAD patients.

Purpose of the Study:

  • To underscore the importance of cholesterol lowering in CAD management.
  • To highlight the role of LDL-C in CAD pathogenesis and treatment.
  • To reinforce the clinical significance of achieving target LDL-C levels.

Main Methods:

  • Review of established scientific literature on cholesterol and CAD.
  • Analysis of clinical trial data demonstrating the efficacy of LDL-C reduction.
  • Interpretation of expert panel recommendations regarding LDL-C goals.

Main Results:

  • Confirmation of a strong association between high LDL-C and CAD.
  • Demonstration of significant reductions in mortality with LDL-C lowering therapies.
  • Adoption of a 100 mg/dL LDL-C goal by the National Cholesterol Education Program.

Conclusions:

  • Cholesterol lowering is a vital strategy for preventing and managing CAD.
  • Achieving recommended LDL-C targets is essential for improving patient outcomes.
  • Effective LDL-C management contributes to reduced cardiovascular morbidity and mortality.