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Pigmented villonodular synovitis of joints.
Henry Mankin1, Carol Trahan, Francis Hornicek
1Department of Orthopaedics, Massachusetts General Hospital, Boston, Massachusetts, USA. hmankin@partners.org
Journal of Surgical Oncology
|March 15, 2011
Summary
Pigmented villonodular disease of joints (PVNS) is a rare condition, most often affecting the knee and foot. Surgical excision is the primary treatment, generally successful at these sites but posing challenges for other joints like the hip.
Area of Science:
- Orthopedic Surgery
- Oncology
- Pathology
Background:
- Pigmented villonodular disease of joints (PVNS) is a rare neoplastic proliferation of synovial joints.
- Historical data from the Jaffe collection (1920-1968) and recent data from our institution (1972-2009) provide insights into PVNS.
- Comparative analysis of these two cohorts allows for evaluation of disease characteristics and treatment outcomes over time.
Purpose of the Study:
- To compare two distinct case series of pigmented villonodular disease of joints (PVNS) spanning different time periods.
- To analyze demographic data, affected sites, treatment modalities, and outcomes for PVNS patients.
- To assess the long-term efficacy and complications associated with surgical management of PVNS.
Main Methods:
- Utilized a computerized tumor data system to extract information on age, gender, site, treatment, complications, and outcome for 215 current cases (1972-2009).
- Reviewed 62 cases from the Jaffe collection (1920-1968), gathering demographic and site data.
- Compared findings between the historical Jaffe collection and the contemporary hospital series.
Main Results:
- Demographic and site distribution of PVNS were consistent across both study periods.
- The knee and foot were the most commonly affected joints, followed by the hip, shoulder, and hand.
- Surgical excision was the predominant treatment; total hip replacement was necessary for hip involvement. Recurrence rates were low, with no instances of metastatic disease or mortality.
Conclusions:
- Pigmented villonodular disease of joints (PVNS) is a rare condition predominantly affecting the knee and foot.
- Surgical excision is the primary treatment modality and is generally successful in the knee and foot.
- PVNS management presents challenges in other locations, particularly the hip, where total hip replacement may be required.
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