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Updated: Jun 3, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
[Overview of acute encephalitis and encephalopathy]
1Department of Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo.
Acute encephalitis/encephalopathy includes a wide variety of diseases and syndromes. Marked advances have recently been made with regard to their classification, pathophysiology, diagnosis and treatment. Clinical and pathologic features of acute encephalitis are determined by pathogens (mostly viruses), humoral immunity and cellular immunity, and those of acute encephalopathy by cytokine storm, metabolic disorder (mitochondrial, in particular)and excitotoxicity.
Acute encephalitis/encephalopathy includes a wide variety of diseases and syndromes. Marked advances have recently been made with regard to their classification, pathophysiology, diagnosis and treatment. Clinical and pathologic features of acute encephalitis are determined by pathogens (mostly viruses), humoral immunity and cellular immunity, and those of acute encephalopathy by cytokine storm, metabolic disorder (mitochondrial, in particular)and excitotoxicity.
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