Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
Hepatic Encephalopathy01:29

Hepatic Encephalopathy

DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...
Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
Huntington Disease l: Introduction01:21

Huntington Disease l: Introduction

Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Zika Virus Infection].

Brain and nerve = Shinkei kenkyu no shinpo·2026
Same author

Superiority of long peripheral catheters over short peripheral catheters for completing planned infusion therapy in late preterm and term neonates: a retrospective cohort study with competing-risk analysis.

Frontiers in pediatrics·2026
Same author

Utility of the immunoglobulin E crosslinking-induced luciferase expression assay in buckwheat allergy diagnosis.

Allergologia et immunopathologia·2026
Same author

A viral APOBEC3 antagonist distinguishes HHV-6A from HHV-6B.

Nature communications·2026
Same author

Four-year neurodevelopmental outcomes in infants with symptomatic congenital cytomegalovirus disease treated with oral valganciclovir: A prospective follow-up study in Japan.

Brain & development·2026
Same author

Machine learning-based mortality prediction for pediatric fulminant myocarditis using cytokine profiles.

Scientific reports·2026
Same journal

[Development of novel therapeutics for multiple myeloma and improvement of drug lag].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Clinical pharmacy services to patients of immunomodulatory drugs].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Therapeutic drug monitoring of the new anti-myeloma drugs in the treatment of multiple myeloma].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Prognostic value of minimal residual disease assessment using next-generation sequencing in multiple myeloma].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[The evaluation of minimal residual disease in multiple myeloma by an allele-specific oligonucleotide real-time PCR].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Evaluation of minimal residual disease in myeloma by multiparametric flow cytometry].

Nihon rinsho. Japanese journal of clinical medicine·2019
See all related articles

Related Experiment Video

Updated: Jun 3, 2026

In Vivo Imaging Systems (IVIS) Detection of a Neuro-Invasive Encephalitic Virus
10:21

In Vivo Imaging Systems (IVIS) Detection of a Neuro-Invasive Encephalitic Virus

Published on: December 2, 2012

[HHV-6 encephalopathy].

Yoshiki Kawamura1, Tetsushi Yoshikawa

  • 1Department of Pediatrics, Fujita Health University School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|March 16, 2011
PubMed
Summary
This summary is machine-generated.

Human herpesvirus 6 (HHV-6) can cause encephalitis, particularly in immunocompromised patients. Antiviral drugs like ganciclovir or foscarnet may treat HHV-6 encephalitis, especially post-transplant acute limbic encephalitis.

More Related Videos

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Differentiation of the SH-SY5Y Human Neuroblastoma Cell Line
08:07

Differentiation of the SH-SY5Y Human Neuroblastoma Cell Line

Published on: February 17, 2016

Related Experiment Videos

Last Updated: Jun 3, 2026

In Vivo Imaging Systems (IVIS) Detection of a Neuro-Invasive Encephalitic Virus
10:21

In Vivo Imaging Systems (IVIS) Detection of a Neuro-Invasive Encephalitic Virus

Published on: December 2, 2012

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Differentiation of the SH-SY5Y Human Neuroblastoma Cell Line
08:07

Differentiation of the SH-SY5Y Human Neuroblastoma Cell Line

Published on: February 17, 2016

Area of Science:

  • Virology
  • Neurology

Context:

  • Primary human herpesvirus 6 (HHV-6) and HHV-7 infections commonly cause exanthem subitum in infants.
  • While rare, HHV-6 can lead to various forms of encephalopathy, particularly in immunocompromised individuals.

Purpose:

  • To explore the association between HHV-6 reactivation and encephalitis.
  • To identify clinical features and potential treatments for HHV-6 encephalitis, especially in transplant recipients.

Summary:

  • HHV-6 reactivation is linked to encephalitis in immunocompromised patients, notably transplant recipients.
  • Post-transplant acute limbic encephalitis in transplant recipients shows typical amnesia and hippocampal MRI findings, implicating HHV-6.
  • In vitro studies suggest ganciclovir and foscarnet possess antiviral activity against HHV-6, indicating their potential therapeutic use.

Impact:

  • Highlights the need for developing specific treatments for different types of HHV-6 encephalitis.
  • Suggests HHV-6 as an etiological agent for post-transplant acute limbic encephalitis.
  • Provides a basis for considering antiviral therapy in managing HHV-6-associated neurological complications.