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Updated: Jun 3, 2026
04:23
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
[Acute necrotizing encephalopathy]
1Department of Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|March 16, 2011
Summary
Acute necrotizing encephalopathy is a rare neurological disorder primarily affecting children, often following viral infections. While corticosteroids may help, the condition frequently leads to poor outcomes and lasting neurological damage.
Area of Science:
- Neurology
- Pediatrics
- Infectious Diseases
Context:
- Acute necrotizing encephalopathy (ANE) is a severe neurological syndrome.
- Characterized by bilateral thalamic lesions, it predominantly affects children in East Asia.
- Often triggered by viral infections like influenza, presenting with high fever.
Purpose:
- To summarize the key features, triggers, and outcomes of acute necrotizing encephalopathy.
- To highlight the challenges in prognosis and treatment.
- To mention the emerging understanding of its genetic underpinnings.
Summary:
- ANE involves acute encephalopathy with specific thalamic lesions, neurological deficits (coma, convulsions, brainstem dysfunction), and systemic organ involvement.
- Viral infections are common preceding factors.
- Despite corticosteroid use in some instances, mortality and severe neurological sequelae remain high.
Impact:
- Highlights the critical need for early diagnosis and management of ANE.
- Emphasizes the poor prognosis and significant long-term neurological impact on affected children.
- Suggests that understanding the genetic basis may offer future therapeutic targets.
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