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Related Experiment Video

Updated: Jun 3, 2026

Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells

Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells

Published on: July 16, 2013

Ciliary beat co-ordination by calcium.

Andreas Schmid¹, Matthias Salathe

¹Division of Pulmonary and Critical Care and Sleep Medicine, Miller School of Medicine, University of Miami, RMSB R-47, 1600 NW 10th Avenue, Miami, FL 33136, U.S.A.

Biology of the Cell

|March 16, 2011

Summary

Calcium ions regulate the beating and synchronization of motile cilia in airway epithelial cells, crucial for mucociliary clearance and airway defense against inhaled particles.

Area of Science:

Cell Biology
Respiratory Physiology

Background:

Motile cilia on airway epithelium drive mucociliary clearance, essential for removing inhaled particles.
Cilia beat frequency is regulated by various mechanisms, including intracellular calcium levels.

Purpose of the Study:

To provide an overview of the multifaceted roles of calcium in regulating the beating of motile cilia in the airways.

Main Methods:

This article is a review, synthesizing existing research on ciliary function and calcium signaling.

Main Results:

Calcium influences both the frequency of ciliary beat and the synchronization of ciliary activity within and between cells.
Intracellular calcium concentration is modulated by purinergic and acetylcholine receptors.

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Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells

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Published on: July 16, 2013

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Observation of the Ciliary Movement of Choroid Plexus Epithelial Cells Ex Vivo

Observation of the Ciliary Movement of Choroid Plexus Epithelial Cells Ex Vivo

Published on: July 13, 2015

Conclusions:

Calcium plays a critical role in modulating ciliary beat frequency and synchronization, impacting overall airway clearance efficiency.
Understanding calcium's role is key to comprehending airway defense mechanisms.