Randomized trial of Internet-based relapse prevention for partially remitted depression

Area of Science:

• Psychiatry
• Psychology
• Digital Health

Background:

• Major depression often involves relapse, even after initial treatment.
• Partial remission leaves individuals vulnerable to recurrent depressive episodes.
• Internet-based interventions offer accessible treatment options.

Purpose of the Study:

• To evaluate the efficacy of Internet-based cognitive behaviour therapy (CBT) in preventing relapse.
• To assess relapse prevention in patients with partially remitted major depression.
• To compare Internet-based CBT with a control group for relapse rates.

Main Methods:

• Randomized controlled trial with 84 participants (71 women, 13 men).
• Intervention group received 10 weeks of Internet-based CBT with therapist support.
• Control group received self-help material. Relapse was monitored via self-ratings and diagnostic interviews.

Main Results:

• Significantly lower relapse rates in the Internet-based CBT group (10.5%) compared to the control group (37.8%).
• Relapse rate differences emerged early and persisted at 6-month follow-up.
• A trend towards greater depressive symptom reduction and higher remission rates in the CBT group.

Conclusions:

• Internet-based CBT is a promising strategy for preventing relapse in major depression.
• The intervention appears effective for individuals in partial remission.
• Digital mental health interventions can support long-term recovery.