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Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

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Correlation between invasive pattern and immunophenotypic alterations in endocervical adenocarcinoma.

Colin J R Stewart¹, Maxine L Crook, Leonie Little

¹Department of Histopathology, King Edward Memorial Hospital, Perth, WA, Australia. colin.stewart@health.wa.gov.au

|March 16, 2011

Summary

Epithelial-mesenchymal transition (EMT) is linked to infiltrative growth in endocervical adenocarcinoma. These changes involve altered cell appearance and specific molecular markers at the invasive front, suggesting a role in tumour progression.

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Area of Science:

Oncology
Pathology
Cell Biology

Background:

Endocervical adenocarcinoma is a significant gynecological malignancy.
Epithelial-mesenchymal transition (EMT) is a cellular process implicated in cancer invasion and metastasis.
Understanding EMT in endocervical cancer can provide insights into tumor progression.

Purpose of the Study:

To investigate the immunophenotypic alterations associated with EMT in endocervical adenocarcinoma.
To correlate these EMT-related changes with tumor morphology and growth patterns.
To explore the potential role of EMT in the pathogenesis of endocervical neoplasms.

Main Methods:

Immunohistochemical analysis of 27 endocervical adenocarcinomas using markers for vimentin, cyclin D1, E-cadherin, beta-catenin, p16, and cytokeratin 7.
Assessment of tumor differentiation and growth patterns, focusing on the invasive front.
Correlation of molecular findings with observed morphological features.

Main Results:

Moderately differentiated endocervical adenocarcinomas with infiltrative components showed reduced E-cadherin and beta-catenin expression at the cell membrane.
Expression of cyclin D1 and, in some cases, vimentin was observed in these infiltrative areas.
Cytological alterations including loss of polarity and cytoplasmic eosinophilia were noted in foci with EMT markers.
Poorly differentiated tumors did not exhibit consistent EMT-related changes.

Conclusions:

Infiltrative growth patterns in endocervical adenocarcinoma are associated with immunophenotypic changes indicative of EMT.
These EMT-associated changes are frequently accompanied by morphological alterations and have a specific distribution.
EMT may be a key mechanism driving the progression of certain endocervical adenocarcinomas.