Related Experiment Video
Updated: Jun 3, 2026

Induction of Adhesion-dependent Signals Using Low-intensity Ultrasound
Published on: May 8, 2012
Vacuum-assisted closure therapy leads to an increase in plasma fibronectin level
Emrah Arslan1, Ozlem Goruroglu Ozturk, Alper Aksoy
1Çanakkale Onsekiz Mart University Plastic and Reconstructive Surgery, Canakkale, Turkey. cleohus@gmail.com
Abstract:
An extensive research has been performed to investigate the mechanisms of action by which the application of subatmospheric pressure to wounds increases the rate of healing. Increased blood flow with vacuum-assisted closure (VAC) use is the most popular aspect. Fibronectin, which is an adhesion molecule, has several functional domains mediating chemotaxis, adhesion and migration. This is thereby involved in differentiation, proliferation, inflammation and thus in wound healing. In this study, plasma fibronectin levels were measured before and after VAC in patients with wounds. The results showed that there was an increase in pre- and post-VAC levels of plasma fibronectin. This statistically significant increase could be another explanation of how VAC therapy promotes wound healing.
Related Concept Videos
Clot Retraction and Fibrinolysis
Fibronectins Connect Cells with ECM
Both proteoglycans and collagen are attached to fibronectin proteins, which, in turn, are attached to integrin proteins. These integrin proteins interact with transmembrane...
Intracellular Signaling Affects Focal Adhesions
Some...
