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Growth standards of infants with Prader-Willi syndrome
Merlin G Butler1, Jennifer Sturich, Jaehoon Lee
1Department of Psychiatry, Kansas University Medical Center, 3901 Rainbow Blvd, MS 4015, Kansas City, KS 66160, USA. mbutler4@kumc.edu
Insights
This study presents standardized growth curves for infants with Prader-Willi syndrome (PWS), offering crucial tools for monitoring growth and comparing PWS infant data. These charts aid in assessing nutritional status and treatment responses.
Area of Science:
- Pediatric Endocrinology
- Genetics and Genetic Diseases
- Growth and Development
Background:
- Prader-Willi syndrome (PWS) is a complex genetic disorder affecting growth and development.
- Standardized growth monitoring tools are essential for managing infants with PWS.
- Existing growth data for PWS infants often lacks standardization, hindering accurate assessment.
Purpose of the Study:
- To generate and report standardized growth curves for non-growth hormone-treated white infants with PWS.
- To provide reference data for weight, length, head circumference, weight/length, and BMI from 0 to 36 months.
- To facilitate comparison of growth patterns among infants with PWS and with normative data.
Main Methods:
- Anthropometric data from 186 white infants (108 boys, 78 girls) with PWS aged 0-36 months were analyzed.
- Standardized growth curves were developed using the LMS smoothing procedure for key growth parameters.
- Calculated percentiles (3rd-97th) and plotted against Centers for Disease Control and Prevention (CDC) 2003 normative data.
Main Results:
- Five standardized growth curves were created for weight, length, head circumference, weight/length, and BMI.
- The curves represent 7 percentile ranges for non-growth hormone-treated white infants with PWS (0-36 months).
- Normative 50th percentile data was plotted on each PWS growth curve for comparison.
Conclusions:
- The developed growth standards are recommended for evaluating infants with PWS.
- These charts facilitate monitoring growth patterns and nutritional assessments.
- The standards can aid in evaluating responses to growth hormone therapy in PWS patients.
Objective:
To generate and report standardized growth curves for weight, length, head circumference, weight/length, and BMI for non-growth hormone-treated white infants (boys and girls) with Prader-Willi syndrome (PWS) between 0 and 36 months of age. The goal was to monitor growth and compare data with other infants with PWS.
Methods:
Anthropometric measures (N = 758) were obtained according to standard methods and analyzed from 186 non-growth hormone-treated white infants (108 boys and 78 girls) with PWS between 0 and 36 months of age. Standardized growth curves were developed and the 3rd, 10th, 25th, 50th, 75th, 90th, and 97th percentiles were calculated by using the LMS (refers to λ, μ, and σ) smoothing procedure method for weight, length, head circumference, weight/length, and BMI along with the normative 50th percentile using Centers for Disease Control and Prevention national growth data from 2003. The data were plotted for comparison purposes.
Results:
Five separate standardized growth curves (weight, length, head circumference, weight/length, and BMI) representing 7 percentile ranges were developed from 186 non-growth hormone-treated white male and female infants with PWS aged 0 to 36 months, and the normative 50th percentile was plotted on each standardized infant growth curve.
Conclusions:
We encourage the use of these growth standards when examining infants with PWS and evaluating growth for comparison purposes, monitoring for growth patterns, nutritional assessment, and recording responses to growth hormone therapy, commonly used in infants and children with PWS.
