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Updated: Jun 3, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

Poststroke depression and treatment effects on functional outcomes.

A A Schmid¹, K Kroenke, H C Hendrie

¹Roudebush VAMC, 1481 W. 10th Street, 11H, Indianapolis, IN 46202-5199, USA. arlene.schmid@va.gov

|March 16, 2011

Summary

Poststroke depression (PSD) severity at baseline is linked to functional dependence after stroke. While improvement in PSD may not directly impact recovery, treating depression is crucial for patient well-being.

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Area of Science:

Neurology
Psychiatry
Rehabilitation Medicine

Background:

Poststroke depression (PSD) is a frequent complication following stroke.
The precise relationship between PSD and functional recovery remains unclear.
This study investigates the link between baseline PSD and later function, and the effect of depression improvement.

Purpose of the Study:

To determine the relationship between poststroke depression (PSD) at baseline and functional outcomes 12 weeks later.
To assess if improvement in depression symptoms impacts 12-week functional recovery in stroke survivors with PSD.

Main Methods:

Secondary analysis of a cohort study including participants with and without PSD.
Logistic regression used to identify factors associated with 12-week functional dependence.

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Effect of Yi-Nao-Jie-Yu Prescription on Post-Stroke Depression in Rats using Middle Cerebral Artery Occlusion Combined with Behavioral Restraint

Effect of Yi-Nao-Jie-Yu Prescription on Post-Stroke Depression in Rats using Middle Cerebral Artery Occlusion Combined with Behavioral Restraint

Published on: January 9, 2026

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Last Updated: Jun 3, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

Effect of Yi-Nao-Jie-Yu Prescription on Post-Stroke Depression in Rats using Middle Cerebral Artery Occlusion Combined with Behavioral Restraint

Effect of Yi-Nao-Jie-Yu Prescription on Post-Stroke Depression in Rats using Middle Cerebral Artery Occlusion Combined with Behavioral Restraint

Published on: January 9, 2026

Analysis conducted on the total cohort (367 participants) and the PSD subgroup (174 participants).

Main Results:

In the PSD cohort, increased medical comorbidity, stroke severity, and baseline depression severity were independently associated with 12-week functional dependence.
Depression severity (PHQ-9 scores) was significantly higher in dependent individuals compared to independent individuals at 12 weeks in both the entire cohort and the PSD subgroup.
Odds ratios indicated significant associations: medical comorbidity (OR 1.10), stroke severity (OR 1.42), and baseline depression severity (OR 1.13).

Conclusions:

Baseline depression severity is associated with functional dependence 12 weeks poststroke.
The study results are inconclusive regarding whether depression improvement independently influences functional recovery.
Identifying and treating PSD is vital due to its symptom burden and association with adverse health and social outcomes, irrespective of direct impact on functional recovery.