Related Experiment Videos
[Dehydroepiandrosterone sulfate (DHEAS) concentration changes in clomiphene therapy?]
R M van der Weiden1, J C Hage, A R Helbing
1Frauenklinik und Medizinisch-Diagnostisches Laboratorium, Rotterdam, Niederlande.
Geburtshilfe Und Frauenheilkunde
|March 1, 1990
Summary
Clomiphene citrate treatment did not alter dehydroepiandrosterone sulfate (DHEAS) levels during ovulation. This suggests DHEAS does not negatively impact follicle development when using clomiphene for ovulation induction.
Area of Science:
- Reproductive Endocrinology
- Endocrinology
- Gynecology
Context:
- Anovulatory infertility affects numerous women globally.
- Clomiphene citrate is a common ovulation induction agent.
- The role of androgens like DHEAS in ovulation is not fully understood.
Purpose:
- To investigate the impact of clomiphene citrate on dehydroepiandrosterone sulfate (DHEAS) levels.
- To determine if DHEAS levels change during the preovulatory phase in anovulatory patients treated with clomiphene.
- To assess the potential negative influence of DHEAS on follicle ripening.
Summary:
- Plasma DHEAS levels were monitored in 10 anovulatory patients treated with clomiphene citrate and 6 ovulatory controls.
- Ovulation was confirmed by luteal phase progesterone levels (≥13 nmol/l) in both groups.
- No significant preovulatory increase in DHEAS levels was observed in either the treatment or control group.
Impact:
- Findings suggest that clomiphene citrate treatment does not significantly alter DHEAS levels during the preovulatory phase.
- The study indicates that DHEAS is unlikely to exert a negative influence on follicle maturation with clomiphene citrate use.
- This research contributes to understanding the hormonal milieu during ovulation induction.