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Related Experiment Videos

Lymphocyte subset responses to repeated submaximal exercise in men.

L Hoffman-Goetz1, J R Simpson, N Cipp

  • 1Department of Health Studies, University of Waterloo, Ontario, Canada.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|March 1, 1990
PubMed
Summary

Repeated exercise sessions decreased T-lymphocytes but significantly increased natural killer (NK) cells in untrained men. This suggests exercise impacts immune cell populations, particularly boosting NK cell activity.

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Area of Science:

  • Immunology
  • Exercise Physiology
  • Sports Science

Background:

  • Immune cell function can be modulated by physical activity.
  • Understanding the impact of exercise on lymphocyte subsets is crucial for health and performance.

Purpose of the Study:

  • To investigate the effects of repeated submaximal cycle ergometry on peripheral blood T-lymphocytes and natural killer (NK) cells.
  • To analyze changes in T-helper/inducer (CD4+) and T-cytotoxic/suppressor (CD8+) subsets following exercise.

Main Methods:

  • 18 healthy, untrained young men participated in a 5-day cycle ergometry protocol.
  • Blood samples were analyzed using fluorescence-activated flow cytometry for lymphocyte subsets (CD3+, CD4+, CD8+) and NK cells (Leu7+).
  • Comparisons were made between pre- and post-exercise measurements on days 1, 3, and 5.

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Main Results:

  • A decrease in T-lymphocytes (CD3+) was observed post-exercise on days 1 and 3.
  • T-helper/inducer cells (CD4+) decreased post-exercise on day 3.
  • A significant increase in natural killer (NK) cells was noted after exercise on days 1 and 3, with a corresponding increase in total NK cell count.

Conclusions:

  • Repeated exercise bouts transiently alter T-lymphocyte percentages.
  • Exercise demonstrably enhances NK cell activity and numbers in previously untrained individuals.
  • These findings highlight the dynamic relationship between acute exercise and innate immune responses.