Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Multiple Sclerosis l: Introduction

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Long-Term Vascular Remodeling After Headache-Onset Intracranial Vertebral Artery Dissection.

AJNR. American journal of neuroradiology·2026

Same author

Plasma autoantibodies as novel risk markers for stroke: A nested case-control study of the JPHC study.

Clinica chimica acta; international journal of clinical chemistry·2026

Same author

[Successful combination therapy with fostamatinib and romiplostim in refractory immune thrombocytopenia 27 years after onset].

[Rinsho ketsueki] The Japanese journal of clinical hematology·2026

Same author

Molecular and clinical features of a Japanese medulloblastoma cohort: Subgroup-specific prognostic stratification using economical/accessible diagnostic methods.

Brain pathology (Zurich, Switzerland)·2026

Same author

Folliculosebaceous Poromas With PAK2 and PAK3 Rearrangements: A Report of Two Cases and Review of the Literature.

The Journal of dermatology·2025

Same author

A case of juvenile chronic encapsulated intracerebral hematoma requiring differential diagnosis, successfully treated with craniotomy and hematoma evacuation.

Surgical neurology international·2025

Search research articles

Related Experiment Video

Updated: Jun 3, 2026

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

[A case of aggressive multiple myeloma].

Yuzo Oda¹, Shinji Ooi, Akira Endoh

¹Dept. of Hematology, Immunology and Nephrology, Matsue Red Cross Hospital, Japan.

Gan to Kagaku Ryoho. Cancer & Chemotherapy

|March 16, 2011

Summary

Aggressive multiple myeloma led to pancytopenia and rapid decline despite initial melphalan-prednisolone and subsequent bortezomib therapies. The patient experienced treatment side effects and ultimately succumbed to the advanced malignancy.

More Related Videos

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

Published on: May 1, 2015

Related Experiment Videos

Last Updated: Jun 3, 2026

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

Published on: May 1, 2015

Area of Science:

Hematology
Oncology
Pathology

Background:

A 64-year-old male presented with pancytopenia, indicative of a potential hematological malignancy.
Initial investigations revealed bone marrow morphology consistent with multiple myeloma and detection of an IgG-kappa M component in urine.

Observation:

The patient was treated with melphalan and prednisolone as an outpatient, but pancytopenia progressed.
Bortezomib therapy was initiated during hospitalization, leading to gastrointestinal side effects.
Chemotherapy was discontinued due to adverse events.

Findings:

Autopsy revealed significant plasma cell infiltration (39%) in atrial blood, with minor infiltration in the liver, kidney, and vessels.
Despite initial treatment, the disease advanced rapidly, leading to a fatal outcome.
The absence of plasma cells in peripheral blood two days prior to death suggests a rapid, terminal phase of the disease.

Implications:

This case highlights the aggressive nature of some multiple myeloma presentations.
It underscores the challenges in managing treatment-related side effects in advanced hematological malignancies.
The rapid progression and fatal outcome emphasize the need for vigilant monitoring and potentially novel therapeutic strategies for aggressive multiple myeloma.