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Related Experiment Video

Updated: Jun 3, 2026

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease
06:06

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Published on: May 9, 2022

Antibiotic prophylaxis in third molar surgery.

Sanjay Pasupathy1, Mohan Alexander

  • 1Department of Oral and Maxillofacial Surgery, Sri Manakula Vinayagar Medical College and Hospital, Kalitheerthalkuppam, Pondicherry, Union Territory, India.

The Journal of Craniofacial Surgery
|March 16, 2011
PubMed
Summary

Prophylactic antibiotics did not significantly reduce surgical wound infections in patients undergoing mandibular third molar removal. This study found no advantage in routine antibiotic use for this procedure.

Related Experiment Videos

Last Updated: Jun 3, 2026

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease
06:06

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Published on: May 9, 2022

Area of Science:

  • Oral and Maxillofacial Surgery
  • Infectious Disease Prevention
  • Pharmacology

Background:

  • Surgical site infections are a potential complication of impacted third molar extraction.
  • The role of prophylactic antibiotics in preventing these infections remains debated.

Purpose of the Study:

  • To evaluate the efficacy of prophylactic antibiotics in reducing surgical wound infections following mandibular impacted third molar removal.

Main Methods:

  • A randomized controlled trial involving 89 patients.
  • Patients were allocated to three groups: placebo, amoxicillin (1g orally 1h pre-surgery), or metronidazole (800mg orally 1h pre-surgery).

Main Results:

  • An overall surgical wound infection rate of 5.61% was observed across all groups.
  • Infection rates were 10.33% for placebo, 6.45% for amoxicillin, and 0% for metronidazole.
  • No statistically significant difference in infection rates was found between the groups.

Conclusions:

  • Routine prophylactic antibiotic use did not demonstrate a statistically significant advantage in preventing surgical wound infections after mandibular third molar removal.
  • Further research may be warranted to explore specific patient populations or antibiotic regimens.