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Fundal changes in children receiving Vigabatrin

Devendra Mishra1, Veena Kalra, Pradeep Venkatesh

  • 1Child Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, Delhi 110 029, India. drdmishra@gmail.com

Indian Journal of Pediatrics
|March 16, 2011
PubMed

Insights

Ocular toxicity from Vigabatrin (VGB) can cause visual field defects. Simple ophthalmoscopy in pediatric patients detected surface wrinkling retinopathy and abnormal macular reflexes, indicating VGB

Area of Science:

  • Ophthalmology
  • Neurology
  • Pharmacology

Background:

  • Vigabatrin (VGB) is an antiepileptic drug associated with visual field defects.
  • Assessing visual fields in young children and those with cognitive impairments is challenging.

Purpose of the Study:

  • To investigate ophthalmoscopic abnormalities in pediatric patients undergoing Vigabatrin therapy.
  • To determine if simple ophthalmoscopy can detect ocular toxicity from VGB.

Main Methods:

  • Ophthalmoscopy was performed on seven pediatric patients receiving VGB.
  • Patients had a median VGB treatment duration of 9 months (range, 3-32 months).

Main Results:

  • Two out of seven patients (33.3%) exhibited abnormal ophthalmoscopic findings.
  • Abnormalities included surface wrinkling retinopathy and abnormal macular reflexes.
  • Findings align with previous reports on VGB ocular toxicity.

Conclusions:

  • Simple ophthalmoscopy is effective in identifying ocular toxicity associated with Vigabatrin.
  • Ophthalmological examination aids in managing antiepileptic drug (AED) therapy in patients on VGB.

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