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Down's syndrome and thyroid disorder.

S Dinani1, S Carpenter

  • 1Department of Psychiatry, Brentry Hospital, Bristol, England.

Journal of Mental Deficiency Research
|April 1, 1990
PubMed
Summary
This summary is machine-generated.

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Thyroid dysfunction is common in adults with Down's syndrome, with many cases of hypothyroidism and elevated thyroid stimulating hormone (TSH) levels. Regular biochemical screening is recommended for early detection and management.

Area of Science:

  • Endocrinology
  • Genetics
  • Internal Medicine

Background:

  • Down's syndrome is associated with an increased risk of thyroid abnormalities.
  • Thyroid dysfunction can significantly impact the health and well-being of individuals with Down's syndrome.

Purpose of the Study:

  • To assess the prevalence and spectrum of thyroid dysfunction in adults with Down's syndrome.
  • To evaluate the utility of clinical findings versus biochemical screening for diagnosing thyroid disorders in this population.

Main Methods:

  • Biochemical assessment of thyroid status including thyroxine (T4) and thyroid-stimulating hormone (TSH) levels.
  • Analysis of thyroid microsomal auto-antibodies.
  • Correlation of biochemical findings with clinical presentation.

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Main Results:

  • A significant proportion of adults with Down's syndrome exhibited abnormal thyroid function, including hypothyroidism and elevated TSH.
  • Clinical findings were not reliable indicators for diagnosing hypothyroidism.
  • Thyroid microsomal auto-antibodies were present in about one-third of patients, more common in females and those with elevated TSH.

Conclusions:

  • Adults with Down's syndrome have a high prevalence of thyroid dysfunction.
  • Routine biochemical screening for thyroid function is essential in this population.
  • The presence of thyroid auto-antibodies suggests an autoimmune basis for thyroid dysfunction in many cases.