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Updated: Jun 3, 2026
In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration
Published on: June 15, 2018
Value of distal compound muscle action potential duration prolongation in acute inflammatory demyelinating
Yusuf A Rajabally1, Guillaume Nicolas
1Neuromuscular Clinic, Department of Neurology, University Hospitals of Leicester, Leicester General Hospital, Leicester LE5 4PW, UK. yusuf.rajabally@uhl-tr.nhs.uk
Introduction:
The value of distal compound muscle action potential duration (DCMAPD) has not been widely studied in acute inflammatory demyelinating polyneuropathy (AIDP) with electromyography (EMG) equipment at low-cut filter settings <10 Hz, as used in Europe.
Methods:
We retrospectively reviewed the records of 40 patients with AIDP and 40 controls with axonal neuropathy, from Leicester, UK, and Angers, France.
Results:
The best combination of sensitivity/specificity for AIDP using DCMAPD prolongation in any one nerve was offered by cut-offs from two other studies (sensitivity: 90% and 87.5%, respectively; specificity: 92.5% for both). Independent DCMAPD prolongation in any one nerve was better than, or equivalent to, other criteria.
Conclusions:
DCMAPD prolongation in any one nerve, at cut-offs suggested by prior studies, represents a sensitive and specific marker to aid/simplify electrodiagnosis of AIDP in patients studied with EMG equipment with low-cut filter settings of <10 Hz.
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