Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Receptor-mediated Endocytosis01:38

Receptor-mediated Endocytosis

Overview
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Enlargement of the Plasma Membrane01:22

Enlargement of the Plasma Membrane

Cell division and enlargement are processes that require precise control. The control ensures that cell division cannot proceed unless the cell has grown to a specific size. A spherical, dividing cell requires an approximately 1.6X increase in its surface area to double its volume. The secretory pathway also has a significant role in cell membrane enlargement. Secretory vesicles that bud off from the Golgi apparatus and later fuse with the plasma membrane during exocytosis are a major source of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cross-Linked Diselenide Nanovesicles against Acute Liver Injury by Seamless Integration of ROS Elimination and Source Inhibition.

ACS applied materials & interfaces·2026
Same author

Association of metformin with osteoarthritis progression and total joint arthroplasty: evidence from the UK Biobank, a large population-based cohort study.

Clinical rheumatology·2026
Same author

self-assembled pH-responsive antibacterial nanoparticles disturb cell envelope integrity and suppress virulence factors of Streptococcus mutans.

Dental materials : official publication of the Academy of Dental Materials·2026
Same author

Organic sulfur metabolism drives volatile sulfur compound generation during wastewater treatment plant sludge thickening.

Water research·2026
Same author

Elucidating the Feammox nitrogen transformation pathway: Key intermediates and putative multi-species metabolic cooperation in a long-term Feammox-dominant system.

Water research·2026
Same author

A catalytic redox-cycling nanoreactor enables robust oxidative stress amplification for synergistic tumor apoptosis and ferroptosis.

Acta biomaterialia·2026

Related Experiment Video

Updated: Jun 3, 2026

SNARE-mediated Fusion of Single Proteoliposomes with Tethered Supported Bilayers in a Microfluidic Flow Cell Monitored by Polarized TIRF Microscopy
10:58

SNARE-mediated Fusion of Single Proteoliposomes with Tethered Supported Bilayers in a Microfluidic Flow Cell Monitored by Polarized TIRF Microscopy

Published on: August 24, 2016

Controlled release from cleavable polymerized liposomes upon redox and pH stimulation.

Shiyong Zhang1, Yan Zhao

  • 1Department of Chemistry, Iowa State University , Ames, Iowa 50011-3111, United States.

Bioconjugate Chemistry
|March 17, 2011
PubMed
Summary

Researchers developed cleavable polymerized liposomes (CPLs) for drug delivery. These liposomes can be triggered to release their contents under specific conditions, offering a new method for controlled pharmaceutical agent release.

More Related Videos

Synthesis of Gold Nanoparticle Integrated Photo-responsive Liposomes and Measurement of Their Microbubble Cavitation upon Pulse Laser Excitation
12:00

Synthesis of Gold Nanoparticle Integrated Photo-responsive Liposomes and Measurement of Their Microbubble Cavitation upon Pulse Laser Excitation

Published on: February 24, 2016

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes
09:51

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes

Published on: March 3, 2020

Related Experiment Videos

Last Updated: Jun 3, 2026

SNARE-mediated Fusion of Single Proteoliposomes with Tethered Supported Bilayers in a Microfluidic Flow Cell Monitored by Polarized TIRF Microscopy
10:58

SNARE-mediated Fusion of Single Proteoliposomes with Tethered Supported Bilayers in a Microfluidic Flow Cell Monitored by Polarized TIRF Microscopy

Published on: August 24, 2016

Synthesis of Gold Nanoparticle Integrated Photo-responsive Liposomes and Measurement of Their Microbubble Cavitation upon Pulse Laser Excitation
12:00

Synthesis of Gold Nanoparticle Integrated Photo-responsive Liposomes and Measurement of Their Microbubble Cavitation upon Pulse Laser Excitation

Published on: February 24, 2016

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes
09:51

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes

Published on: March 3, 2020

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Liposomes are widely used for drug delivery but often lack stability and controlled release mechanisms.
  • Polymerized liposomes offer enhanced stability, but cleavable systems are needed for triggered release.
  • Surface functionalization is crucial for targeted delivery and controlled release applications.

Purpose of the Study:

  • To synthesize novel cleavable polymerized liposomes (CPLs) using click chemistry.
  • To investigate the triggered depolymerization and content release of these CPLs.
  • To evaluate the potential of CPLs for pharmaceutical agent delivery and controlled release.

Main Methods:

  • A gallate derivative with propargyl groups was synthesized and coupled to palmitoyl oleoyl phosphoethanolamine (POPE).
  • Large unilamellar vesicles (LUVs) were formulated using the modified lipid and common lipids like palmitoyl oleoyl phosphatidyl choline (POPC).
  • Cu(I)-catalyzed click reaction between propargyl and azide groups was used for LUV polymerization, incorporating cleavable disulfide or ketal linkers.

Main Results:

  • Successful synthesis and formulation of cleavable polymerized liposomes (CPLs).
  • Demonstrated triggered depolymerization and release of entrapped contents upon exposure to reducing thiols or acidic conditions.
  • Click reaction enabled simultaneous multivalent surface functionalization during cross-linking.

Conclusions:

  • Cleavable polymerized liposomes (CPLs) were successfully created using a click chemistry approach.
  • These CPLs exhibit triggered release properties, making them suitable for controlled pharmaceutical delivery.
  • The developed CPLs hold significant potential for advancing drug delivery and controlled release technologies.