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Fish oil and baroreceptor function in man.

B Weisser1, A Struck, B O Göbel

  • 1Medizinische Universitäts-Poliklinik, Bonn, Federal Republic of Germany.

Klinische Wochenschrift
|January 1, 1990
PubMed
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Dietary fish oil supplements did not alter blood pressure or norepinephrine response in healthy adults. However, fish oil intake significantly increased heart rate suppression during norepinephrine infusion, indicating altered baroreceptor reflex sensitivity.

Area of Science:

  • Cardiovascular Physiology
  • Nutritional Science
  • Pharmacology

Background:

  • Dietary fish oil, rich in n-3 polyunsaturated fatty acids (PUFAs), is studied for its cardiovascular effects.
  • The arterial baroreceptor reflex is crucial for regulating blood pressure and heart rate.

Purpose of the Study:

  • To investigate the impact of fish oil supplementation on resting blood pressure.
  • To assess the pressor response to norepinephrine (NE) after fish oil intake.
  • To determine changes in baroreceptor reflex sensitivity following n-3 PUFA supplementation.

Main Methods:

  • 10 healthy volunteers (21-35 years) received 6 g/day of n-3 PUFAs (3.6 g EPA, 2.4 g DHA) for six weeks.
  • Resting blood pressure, NE-induced blood pressure response, and heart rate changes were measured before and after supplementation.

Related Experiment Videos

  • Baroreceptor reflex sensitivity was evaluated by the heart rate change during NE infusion.

    • Main Results:

    • Fish oil supplementation did not significantly alter resting blood pressure compared to baseline.
    • No significant changes were observed in blood pressure response to exogenous norepinephrine.
    • Heart rate suppression during norepinephrine infusion was significantly greater after fish oil supplementation (p < 0.01).

    Conclusions:

    • Six weeks of n-3 PUFA supplementation did not affect blood pressure or the pressor response to norepinephrine in normotensive individuals.
    • Fish oil intake appears to enhance the baroreceptor-mediated heart rate withdrawal in response to a pressor stimulus.
    • Further research is warranted to elucidate the mechanisms behind the altered baroreceptor reflex sensitivity.