Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Surfen allergy causing insulin depot S hypersensitivity].

M Kása1, F Borda

  • 1Bács-Kiskun Megyei Tanács Hollós József Kórház-Rendelöintézet, Kecskemét Börgyógyászati Osztály.

Orvosi Hetilap
|May 6, 1990
PubMed
Summary

Three patients experienced allergic skin reactions to Insulin-depot-S-Richter due to surfen, the depot agent. Treatment with surfen-free insulin resolved the reactions, highlighting surfen as a cause of insulin allergy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Relation between preoperative prognostic Onodera's Index and postsurgery complications in the R0 gastric carcinoma resection].

Anales del sistema sanitario de Navarra·2017
Same author

[Predictive pre-treatment value of the Prognostic Nutritional Index on survival in gastric carcinoma].

Anales del sistema sanitario de Navarra·2016
Same author

[Prognostic value of Onodera's index in colorectal cancer survival].

Anales del sistema sanitario de Navarra·2014
Same author

[Tissue expression of mismatch repair proteins and tumor lymphocytic infiltration: prognostic significance in resected colorectal carcinoma].

Anales del sistema sanitario de Navarra·2013
Same author

Endoscopic localization of colorectal cancer: study of its accuracy and possible error factors.

Revista espanola de enfermedades digestivas·2012
Same author

Long-term follow-up of 1,000 patients cured of Helicobacter pylori infection following an episode of peptic ulcer bleeding.

The American journal of gastroenterology·2012

Area of Science:

  • Dermatology
  • Allergology
  • Pharmacology

Background:

  • Insulin therapy is crucial for diabetes management.
  • Depot formulations aim to prolong insulin action.
  • Potential for allergic reactions to excipients exists.

Observation:

  • Three patients developed allergic cutaneous reactions post-Insulin-depot-S-Richter injection.
  • Reactions manifested as skin allergies.
  • Symptoms appeared upon administration of the depot insulin formulation.

Findings:

  • Allergological examinations identified surfen as the causative agent.
  • Surfen is responsible for the depot effect in the formulation.
  • Patients responded positively to subsequent treatment with surfen-free insulin.

Implications:

  • Surfen is a significant allergen in Insulin-depot-S-Richter, causing cutaneous reactions.
  • Identifying and removing allergens like surfen is critical for safe insulin therapy.
  • This highlights the importance of evaluating all components of drug formulations for potential adverse effects.

Related Experiment Videos