[Surfen allergy causing insulin depot S hypersensitivity]

Allergic cutaneous reaction developed in 3 patients upon the use of Insulin-depot-S-Richter injections. Allergological examinations confirmed the eliciting role of surfen, the material being responsible for the depot effect. The patients were treated thereafter with surfen-free insulin. The authors deal also with the side-effects of insulin treatment as well as with certain forms of insulin allergy.