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Roles of Electrolytes: Calcium and Phosphate01:27

Roles of Electrolytes: Calcium and Phosphate

Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
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Chronic Kidney Disease II: Clinical Manifestations01:24

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Updated: Jun 3, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

Phosphate and cardiovascular disease.

Jessica Kendrick1, Bryan Kestenbaum, Michel Chonchol

  • 1Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, USA. Jessica.Kendrick@ucdenver.edu

Advances in Chronic Kidney Disease
|March 17, 2011
PubMed
Summary
This summary is machine-generated.

High phosphate levels, even within normal ranges, increase risks for death and cardiovascular events. Further research is needed to confirm the causal link and guide effective treatments for hyperphosphatemia.

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Last Updated: Jun 3, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
09:40

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Published on: January 19, 2017

Area of Science:

  • Nephrology
  • Cardiology
  • Endocrinology

Background:

  • Hyperphosphatemia is a significant risk factor for mortality, cardiovascular events (CVE), and vascular calcification in patients with and without kidney disease.
  • Elevated serum phosphate levels, even within the typical laboratory range, are associated with increased risks of death and CVE.

Purpose of the Study:

  • To explore the mechanisms linking elevated phosphate to adverse outcomes.
  • To highlight the urgent need for clinical trials to establish a causal relationship between phosphate levels and cardiovascular disease.

Main Methods:

  • Review of existing epidemiologic data and evidence on potential biological mechanisms.
  • Identification of knowledge gaps regarding the direct effects of phosphate on vascular health and hormonal pathways.

Main Results:

  • Current evidence suggests direct phosphate effects on vascular calcification.
  • Phosphate influences key hormones like fibroblast growth factor-23 and calcitriol.
  • Epidemiologic data strongly link phosphate excess to cardiovascular disease.

Conclusions:

  • The precise mechanisms of phosphate-induced adverse outcomes require further elucidation.
  • Large, randomized clinical trials with hard endpoints are essential to prove or disprove the benefits and risks of phosphate-lowering therapies.