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Updated: Jun 3, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
Aggregated serum free light chains may prevent adequate removal by high cut-off haemodialysis
Stephen Harding1, Francois Provot, Jean-Baptise Beuscart
1The Binding Site, Birmingham, UK. stephen.harding@bindingsite.co.uk
Abstract:
Free light chain (FLC) removal by high cut-off haemodialysis has been described as an adjuvant therapy for the management of patients with severe renal failure complicating multiple myeloma. The two cases reported here are the first patients in whom this treatment did not remove FLCs. In both patient's sera, size-exclusion chromatography identified large FLC aggregates, with molecular weights above the cut-off of the dialyser. It is important for clinicians to be aware of FLC aggregates as a reason for failure to remove FLCs by this new modality.
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