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Investigation of primary cilia in the pathogenesis of biliary atresia

Jane L Hartley1, Christopher O'Callaghan, Sandro Rossetti

  • 1The Liver Unit, Birmingham Children's Hospital, Birmingham, UK. Jane.Hartley@bch.nhs.uk

Journal of Pediatric Gastroenterology and Nutrition
|March 17, 2011
PubMed
Abstract

No abstract available in PubMed .

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The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...

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