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Related Experiment Video

Updated: Jun 3, 2026

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
08:34

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

Rapid cellular turnover in adipose tissue.

Alessandra Rigamonti1, Kristen Brennand, Frank Lau

  • 1Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, United States of America.

Plos One
|March 17, 2011
PubMed
Summary

Adipose tissue in mice shows rapid cell turnover, with 1-5% of fat cells replaced daily. This discovery opens new therapeutic possibilities for obesity treatment.

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Area of Science:

  • Cellular biology
  • Metabolic research
  • Obesity studies

Background:

  • Cellular turnover was recently demonstrated in human fat cells.
  • Understanding adipose tissue dynamics is crucial for metabolic health.

Purpose of the Study:

  • To quantify the rate of cellular turnover in murine adipose tissue.
  • To investigate the regenerative capacity of fat cells.

Main Methods:

  • Utilized three independent experimental methods: H2BGFP dilution, Ki67 labeling, and BrdU incorporation.
  • Assessed preadipocyte replication and adipocyte replacement rates in mice.

Main Results:

  • Observed significant cellular turnover in murine adipose tissue.
  • Found that 4.8% of preadipocytes replicate, and 1-5% of adipocytes are replaced daily.

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Adipocyte-Specific ATAC-Seq with Adipose Tissues Using Fluorescence-Activated Nucleus Sorting
11:11

Adipocyte-Specific ATAC-Seq with Adipose Tissues Using Fluorescence-Activated Nucleus Sorting

Published on: March 17, 2023

Related Experiment Videos

Last Updated: Jun 3, 2026

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
08:34

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

Adipocyte-Specific ATAC-Seq with Adipose Tissues Using Fluorescence-Activated Nucleus Sorting
11:11

Adipocyte-Specific ATAC-Seq with Adipose Tissues Using Fluorescence-Activated Nucleus Sorting

Published on: March 17, 2023

Conclusions:

  • Adipose tissue exhibits a dynamic cellular turnover process.
  • Adipose tissue regeneration presents a potential therapeutic target for obesity.