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Related Experiment Video

Updated: Jun 3, 2026

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

Published on: January 7, 2019

Venlafaxine-induced mania.

K Jagadheesan¹, R Sandil, D Ram

¹K. JAGADHEESAN, M.D., Senior Resident, Central Institute of Psychiatry, Kanke, Ranchi-834006. jagpsy@yahoo.com.

Indian Journal of Psychiatry

|March 17, 2011

Summary

This summary is machine-generated.

Venlafaxine, an antidepressant, can induce mania in bipolar disorder patients. This case report explores the neurochemical factors contributing to this adverse effect, highlighting a potential risk despite its efficacy.

Keywords:

Venlafaxine antidepressant-induced mania hypomania mania

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Last Updated: Jun 3, 2026

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

Published on: January 7, 2019

Area of Science:

Neuroscience
Psychiatry
Pharmacology

Background:

Venlafaxine is a widely used antidepressant known for its efficacy and favorable side effect profile compared to traditional antidepressants.
Despite its benefits, venlafaxine carries a risk of inducing manic switch in patients with bipolar disorder.
Literature on venlafaxine-induced mania is limited.

Purpose of the Study:

To report a case of mania induced by venlafaxine.
To discuss the potential neurochemical mechanisms underlying this adverse effect.

Main Methods:

Case report.
Review of relevant neurochemical literature.

Main Results:

A case of venlafaxine-induced mania in a patient with bipolar disorder is presented.
Potential neurochemical underpinnings, such as alterations in neurotransmitter systems, are discussed.

Conclusions:

Venlafaxine can precipitate mania in susceptible individuals, particularly those with bipolar disorder.
Understanding the neurochemical basis is crucial for managing this adverse effect and optimizing treatment strategies.