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Related Experiment Video

Updated: May 12, 2026

Protocol for Plasmodium falciparum Infections in Mosquitoes and Infection Phenotype Determination
14:10

Protocol for Plasmodium falciparum Infections in Mosquitoes and Infection Phenotype Determination

Published on: July 4, 2007

Antigenic variation in Plasmodium falciparum malaria involves a highly structured switching pattern.

Mario Recker1, Caroline O Buckee, Andrew Serazin

  • 1Department of Zoology, University of Oxford, Oxford, United Kingdom. mario.recker@zoo.ox.ac.uk

Plos Pathogens
|March 17, 2011
PubMed
Summary
This summary is machine-generated.

Pathogens like the malaria parasite Plasmodium falciparum evade immunity using antigenic variation. This study reveals a structured switching pathway for var genes, balancing repertoire protection and infection capability.

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Area of Science:

  • Microbiology
  • Immunology
  • Genetics

Background:

  • Pathogenic microbes employ antigenic variation for chronic infections.
  • In Plasmodium falciparum, this involves switching var gene family transcripts.

Purpose of the Study:

  • To explore the in vitro antigenic variation process in cloned Plasmodium falciparum populations.
  • To understand the structured switching pathways of var genes.

Main Methods:

  • Genome-wide analysis of cloned parasite populations.
  • In vitro studies of transcriptional switching.

Main Results:

  • Identified a non-random, structured switch pathway for var gene transcripts.
  • Demonstrated switching between dominant and intermediate transcripts.
  • Showed this pathway balances repertoire safeguarding and infection capability.

Conclusions:

  • Structured switching is crucial in early Plasmodium falciparum infections.
  • Antigenic variation in malaria is a balanced process of parasite switching and immune selection.