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Updated: Jun 3, 2026

Comprehensive Analysis of Drug Response using the FLICK Assay
Published on: June 6, 2025
A population approach to in vitro-in vivo correlation modelling for compounds with nonlinear kinetics
Clare Gaynor1, Adrian Dunne, Cian Costello
1UCD School of Mathematical Sciences, University College Dublin, Belfield, Dublin 4, Ireland. clare.gaynor@ucd.ie
Abstract:
Developing an In Vitro-In Vivo Correlation (IVIVC) model is becoming an important part of the drug development process. Traditional methods such as deconvolution and convolution make the assumption of linearity of the system being studied and are, therefore, unsuitable for use with compounds exhibiting nonlinear kinetics. This study proposes the use of a compartmental approach which may be based on systems of differential equations, a method which can comfortably accommodate nonlinearity. This technique can easily be implemented using existing NONMEM libraries and is an accurate, fast and straightforward method of developing an IVIVC model.
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