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Updated: Jun 3, 2026
06:38
An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
Hepatocellular carcinoma: prevention and therapy
Davendra P S Sohal1, Weijing Sun
1Department of Medicine, Hematology and Oncology, Abramson Cancer Center, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104-4283, USA. davendra.sohal@uphs.upenn.edu
Current Oncology Reports
|March 17, 2011
Summary
Hepatocellular carcinoma (HCC), a severe liver cancer, often arises from chronic liver diseases like viral hepatitis or alcohol use. Prevention and new treatments offer hope for managing this aggressive malignancy.
Area of Science:
- Hepatology
- Oncology
- Gastroenterology
Background:
- Hepatocellular carcinoma (HCC) is a primary liver cancer often linked to chronic liver conditions.
- Key causes include viral hepatitis (HBV, HCV), alcohol abuse, and nonalcoholic steatohepatitis (NASH).
- Heritable conditions like hemochromatosis also increase HCC risk.
Purpose of the Study:
- To outline the etiology and risk factors for hepatocellular carcinoma.
- To discuss current preventive strategies for HCC.
- To review available and emerging therapeutic options for HCC.
Main Methods:
- Literature review of HCC causes and treatments.
- Analysis of risk factors including viral, alcoholic, metabolic, autoimmune, biliary, and genetic factors.
- Evaluation of surgical and systemic treatment outcomes.
Main Results:
- Chronic liver disease is the primary precursor to HCC.
- Effective prevention involves managing underlying liver conditions.
- While surgical options exist, many patients are ineligible, necessitating systemic therapies.
Conclusions:
- Preventing and controlling chronic liver diseases is crucial for HCC prevention.
- Advances in local and systemic therapies are improving HCC management.
- Further research into novel treatments is essential for better patient outcomes.
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