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Related Experiment Video

Updated: Jun 3, 2026

Integration of Miniaturized Solid Phase Extraction and LC-MS/MS Detection of 3-Nitrotyrosine in Human Urine for Clinical Applications

Integration of Miniaturized Solid Phase Extraction and LC-MS/MS Detection of 3-Nitrotyrosine in Human Urine for Clinical Applications

Published on: July 14, 2017

Reference urinary LTE4 levels in normal individuals: a pilot study.

R W Dal Negro¹, M Visconti, C Micheletto

¹Lung Dept., Orlandi Gen. Hospital, Bussolengo, Verona, Italy. rdalnegro@ulss22.ven.it

European Annals of Allergy and Clinical Immunology

|March 18, 2011

Summary

This summary is machine-generated.

Urinary LTE4 levels do not differ by gender in normal individuals. However, urinary LTE4 concentrations significantly decrease with age, particularly in those over 60.

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Integration of Miniaturized Solid Phase Extraction and LC-MS/MS Detection of 3-Nitrotyrosine in Human Urine for Clinical Applications

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Longitudinal Follow-Up of Urinary Tract Infections and Their Treatment in Mice using Bioluminescence Imaging

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Published on: June 14, 2021

Area of Science:

Biochemistry
Clinical Chemistry
Human Physiology

Background:

Establishing reference normal values for urinary Leukotriene E4 (LTE4) is crucial for accurate clinical assessment.
Urinary LTE4 is a biomarker reflecting endogenous production of cysteinyl-leukotrienes.

Purpose of the Study:

To investigate the influence of gender and age on urinary LTE4 levels in a healthy adult population.
To provide data for defining age- and gender-specific reference ranges for urinary LTE4.

Main Methods:

Urinary LTE4 was measured in 124 non-smoking, non-atopic subjects using an immunoenzymatic method.
Statistical analyses included t-tests, ANOVA, and linear regression, with a significance level of p < 0.05.

Main Results:

No significant difference in mean urinary LTE4 levels was observed between males (57.3 pg/ml) and females (57.0 pg/ml).
Linear regression revealed no overall correlation between urinary LTE4 and age.
ANOVA indicated significantly higher urinary LTE4 levels in younger age groups compared to older groups (p < 0.002).

Conclusions:

Gender does not impact normal urinary LTE4 levels.
Urinary LTE4 concentrations show a significant age-dependent decrease, most pronounced in individuals over 60.
Age-specific reference values for urinary LTE4 should be considered for younger and older populations.