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Updated: Jun 3, 2026
A GPC3-targeting Bispecific Antibody, GPC3-S-Fab, with Potent Cytotoxicity
Published on: July 12, 2018
Gpc-3 is a notable diagnostic, prognostic and a latent targeted therapy marker in hepatocellular carcinoma
Zhi-Qiang Zou1, Yu-Ping Ding, Bo Long
1The Center of Diagnosis and Treatment for Liver Diseases in Yantai City (The Infectious Diseases Hospital in Yantai), HuanShan Road 62, Yantai City 264001, ShanDong Province, China.
Background/Aims:
To describe the features of the Gpc-3, explore the significance and value about the role of Gpc-3 in pathological diagnosis and prognostic evaluation of hepatocellular carcinoma.
Methodology:
Take an overview of Gpc-3 expression in hepatocellular carcinoma and its expression of the relationship between the clinicopathological features of hepatocellular carcinoma, analysis the expression of Gpc-3 in liver cell adenoma, heterosexual hyperplasia and hepatitis C.
Results:
The expression of GPC-3 has a certain amount of specificity and sensitivity in hepatocellular carcinoma.
Conclusions:
Gpc-3 is not only a diagnostic and prognostic marker in hepatocellular carcinoma, but also is expected to be an ideal target for the therapy of hepatocellular carcinoma.
