Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Types of Functions I01:26

Types of Functions I

319
Functions are fundamental mathematical tools that capture relationships between variables and describe how one quantity changes in relation to another. Their diverse forms allow them to model various real-world phenomena with precision and flexibility. Among the various categories, algebraic functions are prominent due to their formulation through basic arithmetic operations: addition, subtraction, multiplication, division, and root extraction.Algebraic functions include polynomial, rational,...
319
Types of Functions II01:19

Types of Functions II

207
Trigonometric and exponential functions are essential mathematical tools used to model distinct types of real-world behavior, particularly in periodic and growth-related phenomena. These functions extend the capabilities of basic algebraic models by capturing recurring cycles and rapid changes across various scientific and engineering contexts.Trigonometric functions, such as sine and cosine, are particularly effective for representing periodic phenomena. Their cyclic behavior makes them...
207
Structural Protein Function01:56

Structural Protein Function

30.1K
Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to...
30.1K
Types of Receptors: Internal Receptors01:07

Types of Receptors: Internal Receptors

32.7K
Many cellular signals are hydrophilic and cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind intracellular receptors that reside within the cell cytoplasm or nucleus. Many mammalian steroid hormones and nitric oxide (NO) gas use this cell signaling mechanism.
Similar to membrane-bound receptors, the binding of a ligand to the intracellular receptor of causes a conformational change in the...
32.7K
Types of Receptors: Cell Surface Receptors01:28

Types of Receptors: Cell Surface Receptors

28.0K
Cell-surface receptors, also known as transmembrane receptors, are cell surface, membrane-anchored (integral) proteins that bind to external ligand molecules. This type of receptor spans the plasma membrane and performs signal transduction, converting an extracellular signal into an intracellular signal. Ligands that interact with cell-surface receptors do not have to enter the cell that they affect. Cell-surface receptors are also called cell-specific proteins or markers because they are...
28.0K
Correlations02:20

Correlations

36.6K
Correlation means that there is a relationship between two or more variables (such as ice cream consumption and crime), but this relationship does not necessarily imply cause and effect. When two variables are correlated, it simply means that as one variable changes, so does the other. We can measure correlation by calculating a statistic known as a correlation coefficient. A correlation coefficient is a number from -1 to +1 that indicates the strength and direction of the relationship between...
36.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Coastal methane emissions driven by aerotolerant methanogens using seaweed and seagrass metabolites.

Nature geoscience·2025
Same author

Radiation recall dermatitis: A review of the literature.

Seminars in oncology·2022
Same author

Patient-reported outcomes version of the common terminology criteria for adverse events and quality-of-life linear analogue self-assessment in breast cancer patients receiving radiation therapy: single-institution prospective registry.

Journal of patient-reported outcomes·2022
Same author

Cardiovascular disease-related mortality and factors associated with cardiovascular events in the TREAT Asia HIV Observational Database (TAHOD).

HIV medicine·2019
Same author

Applying recovery biomarkers to calibrate self-report measures of sodium and potassium in the hispanic community health study/study of latinos.

Journal of human hypertension·2017
Same author

Applying recovery biomarkers to calibrate self-report measures of sodium and potassium in the Hispanic Community Health Study/Study of Latinos.

Journal of human hypertension·2017
Same journal

Reducing plastic waste in skin-model research: Sustainable packaging as a practical first step.

The Journal of investigative dermatology·2026
Same journal

Modern serum proteomics in precision medicine: Toward disease stratification and predictive, proactive treatment strategies.

The Journal of investigative dermatology·2026
Same journal

An Integrated Skin Cell Atlas Decodes the Pilosebaceous Unit.

The Journal of investigative dermatology·2026
Same journal

Residual CSB activity explains mild UV-sensitive syndrome phenotype caused by CSB mutations.

The Journal of investigative dermatology·2026
Same journal

Charting a new melanoma risk factor: Satellite Naevus Prevalence in High-Risk and Population-Based Cohorts.

The Journal of investigative dermatology·2026
Same journal

Human keratinocytes and fibroblasts coordinate early cutaneous innate defenses against Candida auris.

The Journal of investigative dermatology·2026
See all related articles

Related Experiment Video

Updated: Feb 15, 2026

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
12:27

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

Published on: June 8, 2022

4.0K

Structural and functional correlation of the human complement receptor type 1.

W W Wong1

  • 1Department of Rheumatology & Immunology, Brigham & Women's Hospital, Boston, Massachusetts 02115.

The Journal of Investigative Dermatology
|June 1, 1990
PubMed
Summary
This summary is machine-generated.

Human complement receptor 1 (CR1) plays key roles in immune responses. Genetic variations in CR1 influence its structure and function, affecting immune complex binding capacity.

More Related Videos

Measuring Erythrocyte Complement Receptor 1 Using Flow Cytometry
07:20

Measuring Erythrocyte Complement Receptor 1 Using Flow Cytometry

Published on: May 19, 2020

7.7K
Correlative Microscopy for 3D Structural Analysis of Dynamic Interactions
13:43

Correlative Microscopy for 3D Structural Analysis of Dynamic Interactions

Published on: June 24, 2013

14.6K

Related Experiment Videos

Last Updated: Feb 15, 2026

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
12:27

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

Published on: June 8, 2022

4.0K
Measuring Erythrocyte Complement Receptor 1 Using Flow Cytometry
07:20

Measuring Erythrocyte Complement Receptor 1 Using Flow Cytometry

Published on: May 19, 2020

7.7K
Correlative Microscopy for 3D Structural Analysis of Dynamic Interactions
13:43

Correlative Microscopy for 3D Structural Analysis of Dynamic Interactions

Published on: June 24, 2013

14.6K

Area of Science:

  • Immunology
  • Molecular Biology
  • Genetics

Background:

  • Human complement receptor 1 (CR1) is a crucial cell surface and soluble plasma protein.
  • CR1 mediates phagocytosis and regulates the complement cascade, vital immune functions.
  • Its structure comprises short consensus repeats (SCR), common in complement regulatory proteins.

Purpose of the Study:

  • To elucidate the structural organization of human CR1.
  • To understand the genetic basis of CR1 structural variations.
  • To explore how CR1 structural differences impact its function in immune complex binding.

Main Methods:

  • CR1 gene cloning and primary structure analysis.
  • Genomic structure analysis of CR1.
  • Comparative sequence homology analysis of CR1 repeats.

Main Results:

  • CR1 is an integral membrane protein with an extracellular portion made of 30 SCRs.
  • The amino-terminal 28 SCRs form four long homologous repeats (LHR), with high sequence homology.
  • Genomic analysis indicates LHRs arose from intragenic DNA duplications, explaining CR1 allotypes with varying C3b/C4b binding sites.

Conclusions:

  • CR1's structure is characterized by tandem LHRs, derived from gene duplications.
  • Allelic variations in LHR number lead to different CR1 allotypes.
  • These structural differences likely result in varied capacities for binding immune complexes and modulating complement activity.