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Related Experiment Video

Updated: Jun 3, 2026

Software for Analysis of Heart Rate and Blood Pressure Time-series Data from the Valsalva Maneuver
14:28

Software for Analysis of Heart Rate and Blood Pressure Time-series Data from the Valsalva Maneuver

Published on: June 27, 2025

Predicting neurally mediated syncope based on pulse arrival time: algorithm development and preliminary results.

Christian Meyer1, Geert Morren, Jens Muehlsteff

  • 1Division of Cardiology, Pulmonology and Vascular Medicine, Heinrich-Heine University, Düsseldorf, Germany. Christian.Meyer@med.uniduesseldorf.de

Journal of Cardiovascular Electrophysiology
|March 18, 2011
PubMed
Summary
This summary is machine-generated.

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Pulse rhythm01:30

Pulse rhythm

Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac muscle...

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Predicting neurally mediated syncope (NMS) is possible using heart rate and pulse wave analysis during head-up tilt testing. This method accurately detected syncopes before symptoms, offering improved patient safety and management.

Area of Science:

  • Cardiology
  • Physiology
  • Medical Technology

Background:

  • Neurally mediated syncope (NMS) is a common condition triggered by orthostatic stress.
  • Circulatory adjustments precede sudden loss of consciousness in NMS.
  • Predicting NMS can prevent patient falls and accidents.

Purpose of the Study:

  • To investigate a syncope warning system using heart rate (HR) and pulse wave analysis.
  • To evaluate the efficacy of two algorithms for NMS prediction during head-up tilt (HUT) testing.

Main Methods:

  • Simultaneous recording of HR and pulse wave during 70° HUT table testing in 14 patients with suspected NMS.
  • Testing two algorithms based on HR and/or pulse arrival time (PAT) for syncope prediction.
  • Alarm triggered when cumulative risk exceeded a threshold calculated within the first 2 minutes of upright posture.

Related Experiment Videos

Last Updated: Jun 3, 2026

Software for Analysis of Heart Rate and Blood Pressure Time-series Data from the Valsalva Maneuver
14:28

Software for Analysis of Heart Rate and Blood Pressure Time-series Data from the Valsalva Maneuver

Published on: June 27, 2025

Main Results:

  • Syncope prediction alarm based on HR and PAT detected all syncopes (n=7) more than 16 seconds before symptoms.
  • No false alarms were generated in patients with negative HUT tests (n=7).
  • Syncope prediction was more accurate using HR slope changes compared to PAT alone.

Conclusions:

  • Predicting NMS is feasible through monitoring HR and peripheral pulse wave onset.
  • This monitoring approach shows potential for improving NMS management and patient outcomes.