Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Drug Regulation01:25

Drug Regulation

Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
Drug Control Governance: Regulatory Bodies and Their Impact01:03

Drug Control Governance: Regulatory Bodies and Their Impact

Drug control governance involves the oversight and regulation of pharmaceuticals to ensure their safety and efficacy while preventing illegal drug use and trafficking. Regulatory bodies, including the US Food and Drug Administration (FDA) and the European Union's European Medicines Agency (EMA), play a central role in this process. These agencies evaluate the safety and efficacy of drugs before they can be marketed. They fund clinical trials and assess the benefits and risks associated with a...
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions01:15

Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions

PK–PD modeling has significantly influenced FDA regulatory decisions, particularly drug approval, dosage optimization, and labeling. These models integrate pharmacokinetics (PK) and pharmacodynamics (PD) to predict drug behavior and effects, aiding in optimizing dosing regimens and enhancing the probability of clinical trial success.One notable example is Nesiritide (Natrecor®), a recombinant human brain natriuretic peptide for treating acute decompensated congestive heart failure (CHF).
Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Consequences of changing illumination procedures in photodynamic therapy.

Photodiagnosis and photodynamic therapy·2026
Same author

Gaussian wave packets in a semi-infinite capillary jet for droplet isolation: Spatial linear analysis and nonlinear simulations.

Physical review. E·2026
Same author

Assessing one-dimensional models for axisymmetric liquid columns through analysis of drop oscillations.

Physical review. E·2022
Same author

The impact of COVID-19 upon student radiographers and clinical training in Latin America.

Radiography (London, England : 1995)·2022
Same author

Cyclic photodynamic therapy delays first onset of actinic keratoses in renal transplant recipients: a 5-year randomized controlled trial with 12-month follow-up.

Journal of the European Academy of Dermatology and Venereology : JEADV·2022
Same author

Ultraviolet radiation exposure to the face in patients with xeroderma pigmentosum and healthy controls: applying a novel methodology to define photoprotection behaviour.

The British journal of dermatology·2021

Related Experiment Video

Updated: Jun 3, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
12:37

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

Sunscreen use: controversies, challenges and regulatory aspects.

M Lodén1, H Beitner, H Gonzalez

  • 1Eviderm Institute AB, Bergshamra Allé 9, SE-17077 Solna, Sweden. marie.loden@eviderm.se

The British Journal of Dermatology
|March 18, 2011
PubMed
Summary

Sunscreens protect skin from UV damage but require balancing efficacy with potential toxicity. New EU standards and evolving safety assessments, including environmental impact, shape future sunscreen development and use.

More Related Videos

Minimal Erythema Dose (MED) Testing
06:24

Minimal Erythema Dose (MED) Testing

Published on: May 28, 2013

Studying Chronic Exposure of Mice to Ultraviolet B Radiation
03:20

Studying Chronic Exposure of Mice to Ultraviolet B Radiation

Published on: August 19, 2025

Related Experiment Videos

Last Updated: Jun 3, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
12:37

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

Minimal Erythema Dose (MED) Testing
06:24

Minimal Erythema Dose (MED) Testing

Published on: May 28, 2013

Studying Chronic Exposure of Mice to Ultraviolet B Radiation
03:20

Studying Chronic Exposure of Mice to Ultraviolet B Radiation

Published on: August 19, 2025

Area of Science:

  • Dermatology
  • Environmental Science
  • Toxicology

Background:

  • Modern lifestyles create mismatches with natural skin protection, necessitating sunscreen use.
  • Sunscreens mitigate risks like erythema, photocarcinogenesis, and photoaging from UV radiation.
  • Balancing sunscreen efficacy with potential human and environmental toxicity of UV filters is crucial.

Purpose of the Study:

  • To review the regulatory landscape and safety assessments of UV filters in sunscreens.
  • To discuss emerging challenges in sunscreen development, including animal testing bans and nanoparticle concerns.
  • To highlight ongoing debates regarding sunscreen use, environmental impact, and vitamin D synthesis.

Main Methods:

  • Review of European Union (EU) regulations and standardization of sunscreen protection measurements.
  • Analysis of toxicological and environmental data used for UV filter authorization.
  • Discussion of current and future challenges in sunscreen safety and consumer use.

Main Results:

  • The EU has standardized sunscreen protection measurements and implemented categories for sun protection.
  • UV filters undergo extensive safety assessments, but new challenges arise from bans on animal testing.
  • Future discussions will likely involve nanoparticles, environmental impact, and vitamin D synthesis.

Conclusions:

  • Sunscreens are essential but require careful management due to UV filter safety and environmental considerations.
  • Evolving regulations and consumer awareness are shaping the future of sunscreen products.
  • Balancing sun protection with vitamin D synthesis remains an important consideration for public health.