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Published on: March 10, 2023
Repeated liver resection for recurrent hepatocellular carcinoma
Wladimir Faber1, Daniel Seehofer, Peter Neuhaus
1Department of General, Visceral and Transplantation Surgery, Charité-Universitätsmedizin, Berlin, Germany. wladimir.faber@charite.de
Journal of Gastroenterology and Hepatology
|March 18, 2011
Summary
Repeated liver resection offers a safe and effective curative option for recurring hepatocellular carcinoma (HCC), significantly improving survival rates in selected patients. However, feasibility is limited by factors like liver function and recurrence patterns.
Area of Science:
- Hepatobiliary surgery
- Surgical oncology
- Gastroenterology
Background:
- Hepatocellular carcinoma (HCC) frequently recurs after initial liver resection.
- Identifying effective treatments for intrahepatic HCC recurrence is crucial.
Purpose of the Study:
- To evaluate the safety and effectiveness of repeat liver resection for intrahepatic HCC recurrence.
- To determine survival outcomes following repeated liver resection for HCC.
Main Methods:
- Retrospective review of a prospective database of 483 patients undergoing curative HCC resection.
- Analysis of 27 patients who underwent 31 repeated liver resections for recurrent HCC between 1990 and 2009.
Main Results:
- Perioperative morbidity was 11% with 0% mortality.
- 1-, 3-, and 5-year overall survival rates after repeat resection were 96%, 70%, and 42%, respectively.
- Tumor dedifferentiation was not observed at recurrence.
Conclusions:
- Repeated liver resection is a safe and valid curative option for selected patients with recurrent HCC.
- This approach can significantly prolong survival compared to other treatments.
- Feasibility is limited in patients with impaired liver function or multifocal/extrahepatic recurrence.
