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Relationship between sleep and acid gastro-oesophageal reflux in neonates

Mohamed Ammari1, Djamal Djeddi, André Léké

  • 1PériTox Laboratory (EA4285-UMI 01 INERIS), Jules Verne University of Picardy, 3 rue des Louvels, Amiens, France.

Journal of Sleep Research
|March 18, 2011
PubMed

Insights

Gastro-oesophageal reflux in neonates occurs more during wakefulness but has a greater impact during sleep. Active sleep promotes acid migration, while quiet sleep risks prolonged acid contact.

Area of Science:

  • Neonatal physiology
  • Gastroenterology
  • Sleep medicine

Background:

  • Gastro-oesophageal reflux (GOR) is common in neonates.
  • Understanding the interplay between GOR and sleep is crucial for infant health.
  • Previous research has not fully elucidated how sleep states influence GOR characteristics.

Purpose of the Study:

  • To investigate the impact of acid reflux on neonatal sleep.
  • To determine how wakefulness (W) and sleep stages affect GOR characteristics.
  • To analyze retrograde bolus migration of oesophageal acid contents during different vigilance states.

Main Methods:

  • Nocturnal polysomnography with pH and multichannel intraluminal impedance monitoring.
  • Study included 25 infants hospitalized for suspected GOR.
  • Infants were divided into reflux and control groups.

Main Results:

  • No significant differences in sleep duration, structure, or state change frequency between groups.
  • GOR occurred more frequently during W (59%) and active sleep (AS; 35%) than quiet sleep (QS; 6%).
  • Mean GOR duration was longer in QS; retrograde bolus migration was higher in AS (62%) than W (42%) and QS (4.5%).

Conclusions:

  • Neonatal GOR occurs more frequently during wakefulness.
  • Sleep state transitions significantly influence GOR patterns and impact.
  • Active sleep facilitates acid migration, while quiet sleep increases the risk of prolonged acid mucosal contact.

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