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Comparison of childhood wheezing phenotypes in 2 birth cohorts: ALSPAC and PIAMA

Olga E Savenije1, Raquel Granell, Daan Caudri

  • 1Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

The Journal of Allergy and Clinical Immunology
|March 18, 2011
PubMed

Insights

Childhood wheezing phenotypes identified in two large birth cohorts were comparable, supporting the existence of an intermediate-onset wheeze pattern. This comparability aids in understanding asthma origins by studying genetic and environmental factors.

Area of Science:

  • Pediatric Allergy and Immunology
  • Respiratory Medicine
  • Epidemiology

Background:

  • Childhood wheezing patterns are diverse and have varying associations with later asthma, atopy, and bronchial hyperresponsiveness (BHR).
  • Novel wheezing phenotypes have been identified using longitudinal data from the Avon Longitudinal Study of Parents And Children (ALSPAC).
  • Replication of these identified phenotypes in independent birth cohorts is crucial for validation.

Purpose of the Study:

  • To compare wheezing phenotypes identified in early childhood (0-8 years) between the ALSPAC and the Prevention and Incidence of Asthma and Mite Allergy (PIAMA) birth cohorts.
  • To validate the identified wheezing phenotypes and their associations with asthma-related outcomes across different populations.

Main Methods:

  • Longitudinal latent class analysis was employed to identify wheezing phenotypes based on repeated wheeze reports from birth to 8 years.
  • Data from 5760 children in the ALSPAC cohort and 2810 children in the PIAMA cohort were analyzed.
  • Phenotypes were compared between cohorts, and associations with asthma, atopy, BHR, and lung function were assessed using weighted regression.

Main Results:

  • A 5-class model demonstrated the best fit for the PIAMA data.
  • Wheezing phenotypes identified in the PIAMA study showed similar patterns to those previously reported in ALSPAC.
  • An intermediate-onset wheeze phenotype, with wheezing starting after 2 years of age, was further supported.
  • Associations between wheezing phenotypes and asthma, atopy, BHR, and lung function were consistent across both cohorts.

Conclusions:

  • Wheezing phenotypes derived from longitudinal latent class analysis are comparable between two large birth cohorts (ALSPAC and PIAMA).
  • These findings provide robust evidence for distinct childhood wheezing phenotypes.
  • Further investigation into the genetic and environmental factors associated with these phenotypes is essential for elucidating the origins of asthma.
Abstract

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