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Updated: Jun 3, 2026

Impact of Intracardiac Neurons on Cardiac Electrophysiology and Arrhythmogenesis in an Ex Vivo Langendorff System
Published on: May 22, 2018
[Neurology and cardiology: points of contact]
Larry B Goldstein1, Nada El Husseini
1Division of Neurology, Department of Medicine, Duke Stroke Center, Duke University Medical Center, Durham, North Carolina, Estados Unidos. golds004@mc.duke.edu
Insights
Neurology and cardiology intersect in managing cardiogenic strokes and heart conditions in neuromuscular disorders. Effective stroke prevention strategies depend on the specific cardiac cause, requiring collaboration between specialists.
Area of Science:
- Cardiology and Neurology
- Cardiovascular Diseases
- Neuromuscular Disorders
Context:
- Approximately 20-30% of strokes are linked to cardiac conditions like atrial fibrillation and heart failure.
- Cardiac interventions can also precipitate strokes.
- Neuromuscular disorders frequently involve cardiac abnormalities.
Purpose:
- To highlight the interdisciplinary nature of managing cardiogenic strokes.
- To review cardiac etiologies of stroke and associated treatments.
- To emphasize the shared responsibility in caring for patients with cardiac and neuromuscular conditions.
Summary:
- Treatment for recurrent stroke prevention varies by etiology; anticoagulation is superior for atrial fibrillation but not definitively for heart failure.
- Anticoagulation is contraindicated in infective endocarditis.
- Ongoing research addresses stroke prevention in patent foramen ovale.
Impact:
- Improved patient outcomes through collaborative care between cardiologists and neurologists.
- Enhanced understanding of stroke prevention strategies tailored to specific cardiac conditions.
- Better management of cardiac comorbidities in patients with neuromuscular disorders.
Abstract:
Strokes resulting from cardiac diseases, and cardiac abnormalities associated with neuromuscular disorders are examples of the many points of contact between neurology and cardiology. Approximately 20-30% of strokes are related to cardiac diseases, including atrial fibrillation, congestive heart failure, bacterial endocarditis, rheumatic and nonrheumatic valvular diseases, acute myocardial infarction with left ventricular thrombus, and cardiomyopathies associated with muscular dystrophies, among others. Strokes can also occur in the setting of cardiac interventions such as cardiac catheterization and coronary artery bypass procedures. Treatment to prevent recurrent stroke in any of these settings depends on the underlying etiology. Whereas anticoagulation with vitamin K antagonists is proven to be superior to acetylsalicylic acid for stroke prevention in atrial fibrillation, the superiority of anticoagulants has not been conclusively established for stroke associated with congestive heart failure and is contraindicated in those with infective endocarditis. Ongoing trials are evaluating management strategies in patients with atrial level shunts due to patent foramen ovale. Cardiomyopathies and conduction abnormalities are part of the spectrum of many neuromuscular disorders including mitochondrial disorders and muscular dystrophies. Cardiologists and neurologists share responsibility for caring for patients with or at risk for cardiogenic strokes, and for screening and managing the heart disease associated with neuromuscular disorders.
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